CAS 153512-23-3

5'-O-(DIMETHOXYTRITYL)-5-[N-(2-(TRIFLUOROACETAMIDO)ETHYL)-3-(E)-ACRYLAMIDO]-2'-DEOXYURIDINE

Description:

5'-O-(Dimethoxytrityl)-5-[N-(2-(trifluoroacetamido)ethyl)-3-(E)-acrylamido]-2'-deoxyuridine is a modified nucleoside that features a deoxyuridine base, which is a component of DNA. The presence of the dimethoxytrityl (DMT) group indicates that this compound is likely used in the synthesis of oligonucleotides, as DMT serves as a protective group for the 5' hydroxyl during the phosphoramidite synthesis process. The trifluoroacetamido group enhances the compound's solubility and stability, while the acrylamide moiety suggests potential reactivity for further chemical modifications or conjugation reactions. This compound is characterized by its ability to participate in nucleophilic reactions, making it valuable in bioconjugation and drug delivery applications. Its structural complexity allows for specific interactions in biochemical pathways, and it may be utilized in research involving gene therapy or the development of nucleic acid-based therapeutics. Overall, this compound exemplifies the intricate design of modified nucleosides for advanced applications in molecular biology and medicinal chemistry.

Formula: C₃₇H₃₇F₃N₄O₉

Synonyms:

• 5'-o-(Dimethoxytrityl)-5-[N-(2-(trifluoroacetamido)ethyl)-3-(E)-acrylamido]-2'-decxyuridine

5''-O-DMT-5-[N-(2-(trifluoroacetamido)ethyl)-3-E-acrylamido]-2''-deoxyuridine

CAS: 153512-23-3

Ref: 7W-GN1325

5'-O-DMT-5-[N-(2-(trifluoroacetamido)ethyl)-3-E-acrylamido]-2'-deoxyuridine

CAS: 153512-23-3

5'-O-DMT-5-[N-(2-(trifluoroacetamido)ethyl)-3-E-acrylamido]-2'-deoxyuridine is a nucleoside analog that is an activator of DNA polymerase. It has been shown to have anticancer activity in vitro and in vivo. 5'-O-DMT-5-[N-(2-(trifluoroacetamido)ethyl)-3-E-acrylamido]-2'-deoxyuridine was found to inhibit the proliferation of leukemia cells, human colon cancer cells, and human prostate cancer cells. This compound also inhibits viral replication by affecting the synthesis of viral DNA and RNA. 5'-O-DMT-5-[N-(2-(trifluoroacetamido)ethyl)-3-E-acrylamido]-2'-deoxyuridine may be used as a research tool for studying the mechanism of action of antiviral drugs such

Formula: C₃₇H₃₇F₃N₄O₉

Purity: Min. 95%

Molecular weight: 738.74 g/mol

Ref: 3D-ND08236