CAS 153536-53-9

NICOTINE-N-B-GLUCURONIDE

Description:

Nicotin-N-b-glucuronide is a metabolite of nicotine, which is primarily found in tobacco products. It is formed through the process of glucuronidation, where a glucuronic acid molecule is conjugated to nicotine, enhancing its solubility and facilitating excretion from the body. This compound is characterized by its molecular structure, which includes a nicotine backbone linked to a glucuronic acid moiety. Nicotin-N-b-glucuronide is typically present in biological fluids, such as urine, and serves as a biomarker for nicotine exposure. Its presence can be indicative of tobacco use and is often studied in pharmacokinetics and toxicology. The compound is generally considered to have lower pharmacological activity compared to nicotine itself, but it plays a significant role in the metabolism and elimination of nicotine from the body. Understanding its characteristics is important for research related to nicotine addiction, tobacco harm reduction, and the overall impact of tobacco consumption on health.

Formula: C₁₆H₂₂N₂O₇

Synonyms:

• NNG
• Nicotine-N--glucuronide Hydrate

Nicotine-N-b-D-glucuronide hydrate

CAS: 153536-53-9

Ref: 7W-GC1453

Nicotine N-Glucuronide

CAS: 153536-53-9

Formula: C₁₆H₂₂N₂O₆

Color and Shape: Pale Yellow Solid

Molecular weight: 338.36

Ref: 4Z-N-0616

Nicotine N-β-D-Glucuronide

CAS: 153536-53-9

Stability Very Hygroscopic
Applications Nicotine N-β-D-Glucuronide is a Nicotine (N412420) metabolite in rat brain. Nicotine N-β-D-Glucuronide is used as a Nicotine biomarker in rat brain.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Alexandrov, K., et al.: Toxicol. Lett., 198, 63 (2010), Huang, L., et al.: J. Neurochem., 109, 826 (2009), Quik, M., et al.: Biochem. Pharmacol., 78, 677 (2009), Weems, J., et al.: Chem. Res. Toxicol., 23, 696 (2010),

Formula: C₁₆H₂₂N₂O₆

Color and Shape: Off-White To Yellow

Molecular weight: 338.36

Ref: TR-N424575

Nicotine-N-b-D-glucuronide hydrate

CAS: 153536-53-9

Nicotine-N-b-D-glucuronide hydrate is a metabolite of nicotine that is excreted in the urine as an organic anion. It has been shown to have anticancer activity against a variety of human cancer cell lines, including lung, stomach, colon, and prostate. Nicotine-N-b-D-glucuronide hydrate has also been shown to inhibit protein synthesis in vitro by interfering with the ability of cells to import amino acids such as tryptophan and phenylalanine. The same study also showed that this metabolite can cause symptoms similar to those caused by nicotine withdrawal.

Formula: C₁₆H₂₂N₂O₆·xH₂O

Purity: Min. 95%

Molecular weight: 338.36 g/mol

Ref: 3D-MN09846

Nicotine N-Glucuronide

CAS: 153536-53-9

Formula: C₁₆H₂₂N₂O₆

Molecular weight: 338.36

Ref: ST-EA-CP-N8020