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CAS 153537-73-6

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Plevitrexed

Description:
Plevitrexed, with the CAS number 153537-73-6, is a synthetic compound classified as an antifolate and is primarily used in the treatment of certain types of cancer, particularly mesothelioma and non-small cell lung cancer. It functions as a potent inhibitor of dihydrofolate reductase (DHFR), an enzyme critical for DNA synthesis and cell division, thereby impeding the proliferation of cancer cells. Plevitrexed is characterized by its structural similarity to folate, allowing it to effectively compete with natural substrates for binding to DHFR. The compound is typically administered intravenously and is often used in combination with other chemotherapeutic agents to enhance therapeutic efficacy. Its pharmacokinetics involve metabolism primarily in the liver, with renal excretion of metabolites. Side effects may include myelosuppression, gastrointestinal disturbances, and potential hypersensitivity reactions. Due to its mechanism of action, Plevitrexed is an important agent in oncological pharmacotherapy, contributing to improved outcomes in patients with specific malignancies.
Formula:C26H25FN8O4
InChI:InChI=1S/C26H25FN8O4/c1-4-9-35(13-16-11-19-22(10-14(16)2)28-15(3)29-25(19)37)17-5-6-18(20(27)12-17)24(36)30-21(26(38)39)7-8-23-31-33-34-32-23/h1,5-6,10-12,21H,7-9,13H2,2-3H3,(H,30,36)(H,38,39)(H,28,29,37)(H,31,32,33,34)/t21-/m0/s1
InChI key:InChIKey=IEJSCSAMMLUINT-NRFANRHFSA-N
SMILES:O=C1C=2C(=CC(C)=C(CN(CC#C)C3=CC(F)=C(C(N[C@@H](CCC=4NN=NN4)C(O)=O)=O)C=C3)C2)NC(C)=N1
Synonyms:
  • (2S)-2-((4-(((2,7-Dimethyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl)(prop-2-ynyl)amino)-2-fluorobenzoyl)amino)-4-(1H-tetrazol-5-yl)butanoic acid
  • (2S)-2-[(4-{[(2,7-dimethyl-4-oxo-1,4-dihydroquinazolin-6-yl)methyl](prop-2-yn-1-yl)amino}-2-fluorobenzoyl)amino]-4-(2H-tetrazol-5-yl)butanoic acid
  • (aS)-a-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid
  • 1H-Tetrazole-5-butanoic acid, α-[[4-[[(1,4-dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-, (S)-
  • 1H-Tetrazole-5-butanoic acid, α-[[4-[[(1,4-dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-, (αS)-
  • Bgc 9331
  • Fluorobenzamido)-4-(1H-Tetrazol-5-Yl)Butyric Acid
  • Nsc 696259
  • Vamidex
  • Zd 9331
  • Plevitrexed
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Found 2 products.
  • Plevitrexed
    TRC
    + Info

    Plevitrexed

    Controlled Product
    CAS:
    Formula:C26H25FN8O4
    Color and Shape:Neat
    Molecular weight:532.53

    Ref: TR-P625000

    25mg
    37,699.00€
  • Plevitrexed
    Targetmol
    + Info

    Plevitrexed

    CAS:
    <p>Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor &amp; reduced folate carrier, treats gastric cancer.</p>
    Formula:C26H25FN8O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:532.53

    Ref: TM-T12635L