CAS 153559-49-0
:Bexarotene
Description:
Bexarotene is a synthetic retinoid, primarily used in the treatment of certain types of cancer, particularly cutaneous T-cell lymphoma. It functions as a selective agonist for retinoid X receptors (RXRs), which play a crucial role in regulating gene expression involved in cell growth and differentiation. Bexarotene is characterized by its ability to induce apoptosis in malignant cells and inhibit their proliferation. The compound is typically administered orally and is known for its relatively favorable pharmacokinetic profile, including good bioavailability. Its chemical structure features a bicyclic core, which is essential for its biological activity. Bexarotene can also influence lipid metabolism, leading to alterations in serum lipid levels, which necessitates monitoring during treatment. Side effects may include hyperlipidemia, hypothyroidism, and skin reactions. Overall, Bexarotene represents a significant advancement in targeted cancer therapies, showcasing the potential of retinoid-based compounds in oncology.
Formula:C24H28O2
InChI:InChI=1/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)
InChI key:InChIKey=NAVMQTYZDKMPEU-UHFFFAOYSA-N
SMILES:CC1(C)C=2C(C(C)(C)CC1)=CC(C)=C(C(=C)C3=CC=C(C(O)=O)C=C3)C2
Synonyms:- 1-Bexarotene
- 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic Acid, SR-11247, LGD-1069, Targretin
- 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
- Benzoic acid, 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-
- LG 69 (retinoid)
- Lg 100069
- Lg 1069
- Lg 69
- Lgd 1069
- Lgd1069
- Ro 26-4455
- Sr 11247
- Targret
- Targretin
- Targretyn
- Targrexin
- Bexaroten
- Bexarotenecas
- Bexarotene(4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)ethenyl]benzoic acid
- Bexarotene(LGD-1069)
- Bexarotene (Targretin
- Bexarotene (Targretin Targrexin)
- Hsdb 7453
- BEXAROTENE
- Bexarotene, Free
- See more synonyms
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Found 14 products.
Bexarotene
CAS:Formula:C24H28O2Purity:>96.0%(HPLC)Color and Shape:White to Orange to Green powder to crystalMolecular weight:348.49Bexarotene, 98%
CAS:<p>Synthetic retinoid analog with specific affinity for the retinoid X receptor</p>Formula:C24H28O2Purity:98%Color and Shape:Powder or crystals or crystalline powder, White to pale yellowMolecular weight:348.48Bexarotene
CAS:<p>Aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacid and their derivatives, nesoi</p>Formula:C24H28O2Color and Shape:White PowderMolecular weight:348.208934-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
CAS:Formula:C24H28O2Purity:95%Color and Shape:SolidMolecular weight:348.4779Ref: IN-DA00389U
1g253.00€10gTo inquire1mg39.00€25gTo inquire50gTo inquire10mg49.00€50mg52.00€250mg111.00€4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Vinyl)Benzoic Acid
CAS:4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Vinyl)Benzoic AcidPurity:98%Molecular weight:348.48g/molBexarotene
CAS:Formula:C24H28O2Purity:≥ 96.0%Color and Shape:White to beige powderMolecular weight:348.48Bexarotene
CAS:Controlled Product<p>Applications Bexarotene is a selective retinoid X receptor (RXR) agonist and an antineoplastic agent (1,2,3).<br>References (1) Boehm, M.F., et al.: J. Med. Che., 37,2930 (1994) (2) Gottardis, M.M., et al.: Cancer Res., 56, 5566 (1996) (3) Mukherjee, R., et al.: Nature, 386, 407 (1997)<br></p>Formula:C24H28O2Color and Shape:NeatMolecular weight:348.48Bexarotene - Bio-X ™
CAS:Controlled Product<p>Bexarotene is a retinoid and antineoplastic agent that is used for the treatment of solid tumours and t-cell lymphomas. It inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin and research has shown that it induces tumor regression in vivo in some animal models.</p>Formula:C24H28O2Purity:Min. 95%Color and Shape:PowderMolecular weight:348.48 g/molBexarotene
CAS:Controlled Product<p>Selective agonist of retinoid X receptor (RXR), permeable to blood-brain barrier and neuroprotective against neurological pathologies such as subarachnoid haemorrhage, traumatic brain injury, ischemic stroke and Alzheimer’s disease. Bexarotene promoted neurogenesis as a treatment of embryonic stem cells affected proliferation of neural progenitors, neuronal differentiation and stimulated neurite outgrowth.</p>Formula:C24H28O2Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:348.48 g/molBexarotene
CAS:<p>Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).</p>Formula:C24H28O2Purity:99% - 99.65%Color and Shape:White SolidMolecular weight:348.48
![4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA00389U.jpg&w=3840&q=75)
