CAS 153559-49-0

Bexarotene

Description:

Bexarotene is a synthetic retinoid, primarily used in the treatment of certain types of cancer, particularly cutaneous T-cell lymphoma. It functions as a selective agonist for retinoid X receptors (RXRs), which play a crucial role in regulating gene expression involved in cell growth and differentiation. Bexarotene is characterized by its ability to induce apoptosis in malignant cells and inhibit their proliferation. The compound is typically administered orally and is known for its relatively favorable pharmacokinetic profile, including good bioavailability. Its chemical structure features a bicyclic core, which is essential for its biological activity. Bexarotene can also influence lipid metabolism, leading to alterations in serum lipid levels, which necessitates monitoring during treatment. Side effects may include hyperlipidemia, hypothyroidism, and skin reactions. Overall, Bexarotene represents a significant advancement in targeted cancer therapies, showcasing the potential of retinoid-based compounds in oncology.

Formula: C₂₄H₂₈O₂

InChI: InChI=1/C24H28O2/c1-15-13-20-21(24(5,6)12-11-23(20,3)4)14-19(15)16(2)17-7-9-18(10-8-17)22(25)26/h7-10,13-14H,2,11-12H2,1,3-6H3,(H,25,26)

InChI key: InChIKey=NAVMQTYZDKMPEU-UHFFFAOYSA-N

SMILES: CC1(C)C=2C(C(C)(C)CC1)=CC(C)=C(C(=C)C3=CC=C(C(O)=O)C=C3)C2

Synonyms:

• 1-Bexarotene
• 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic Acid, SR-11247, LGD-1069, Targretin
• 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid
• Benzoic acid, 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-
• LG 69 (retinoid)
• Lg 100069
• Lg 1069
• Lg 69
• Lgd 1069
• Lgd1069
• Ro 26-4455
• Sr 11247
• Targret
• Targretin
• Targretyn
• Targrexin
• Bexaroten
• Bexarotenecas
• Bexarotene(4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)ethenyl]benzoic acid
• Bexarotene(LGD-1069)
• Bexarotene (Targretin
• Bexarotene (Targretin Targrexin)
• Hsdb 7453
• BEXAROTENE
• Bexarotene, Free

Bexarotene

CAS: 153559-49-0

Formula: C₂₄H₂₈O₂

Purity: >96.0%(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 348.49

Ref: 3B-B4798

Bexarotene, 98%

CAS: 153559-49-0

Synthetic retinoid analog with specific affinity for the retinoid X receptor

Formula: C₂₄H₂₈O₂

Purity: 98%

Color and Shape: Powder or crystals or crystalline powder, White to pale yellow

Molecular weight: 348.48

Ref: 02-J63701

Bexarotene

CAS: 153559-49-0

Aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacid and their derivatives, nesoi

Formula: C₂₄H₂₈O₂

Color and Shape: White Powder

Molecular weight: 348.20893

Ref: 45-1071150

4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid

CAS: 153559-49-0

Formula: C₂₄H₂₈O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 348.4779

Ref: IN-DA00389U

4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Vinyl)Benzoic Acid

CAS: 153559-49-0

4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Vinyl)Benzoic Acid

Purity: 98%

Molecular weight: 348.48g/mol

Ref: 54-OR1011098

Bexarotene

CAS: 153559-49-0

Formula: C₂₄H₂₈O₂

Color and Shape: White To Off-White Solid

Molecular weight: 348.49

Ref: 4Z-B-321

Bexarotene

CAS: 153559-49-0

Bexarotene

Purity: ≥98%

Molecular weight: 348.48g/mol

Ref: 54-BUP15744

Bexarotene

CAS: 153559-49-0

Formula: C₂₄H₂₈O₂

Purity: ≥ 96.0%

Color and Shape: White to beige powder

Molecular weight: 348.48

Ref: 7W-GP4878

Bexarotene-d4

CAS: 153559-49-0

Formula: C₂₄H₂₄D₄O₂

Molecular weight: 352.51

Ref: 4Z-B-322

Bexarotene

Controlled Product

CAS: 153559-49-0

Applications Bexarotene is a selective retinoid X receptor (RXR) agonist and an antineoplastic agent (1,2,3).
References (1) Boehm, M.F., et al.: J. Med. Che., 37,2930 (1994) (2) Gottardis, M.M., et al.: Cancer Res., 56, 5566 (1996) (3) Mukherjee, R., et al.: Nature, 386, 407 (1997)

Formula: C₂₄H₂₈O₂

Color and Shape: Neat

Molecular weight: 348.48

Ref: TR-B336750

Bexarotene

CAS: 153559-49-0

Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).

Formula: C₂₄H₂₈O₂

Purity: 99% - 99.65%

Color and Shape: White Solid

Molecular weight: 348.48

Ref: TM-T6410

Bexarotene, Free Acid

CAS: 153559-49-0

Formula: C₂₄H₂₈O₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 348.486

Ref: 10-F050667

Bexarotene

Controlled Product

CAS: 153559-49-0

Selective agonist of retinoid X receptor (RXR), permeable to blood-brain barrier and neuroprotective against neurological pathologies such as subarachnoid haemorrhage, traumatic brain injury, ischemic stroke and Alzheimer’s disease. Bexarotene promoted neurogenesis as a treatment of embryonic stem cells affected proliferation of neural progenitors, neuronal differentiation and stimulated neurite outgrowth.

Formula: C₂₄H₂₈O₂

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 348.48 g/mol

Ref: 3D-FB18579

Bexarotene - Bio-X ™

Controlled Product

CAS: 153559-49-0

Bexarotene is a retinoid and antineoplastic agent that is used for the treatment of solid tumours and t-cell lymphomas. It inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin and research has shown that it induces tumor regression in vivo in some animal models.

Formula: C₂₄H₂₈O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 348.48 g/mol

Ref: 3D-BB164246