CAS 153559-76-3

6-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-pyridinecarboxylic acid

Description:

6-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-pyridinecarboxylic acid, identified by its CAS number 153559-76-3, is a chemical compound characterized by its complex structure, which includes a pyridine ring and a cyclopropyl group attached to a naphthalene derivative. This compound features multiple methyl groups that contribute to its hydrophobic characteristics and may influence its solubility and reactivity. The presence of the carboxylic acid functional group indicates potential for hydrogen bonding and reactivity in various chemical environments. Its unique structure suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals, where such compounds may exhibit specific biological activities. Additionally, the stereochemistry associated with the cyclopropyl and naphthalene moieties may play a crucial role in the compound's interaction with biological targets. Overall, this compound exemplifies the intricate relationship between molecular structure and chemical properties, which is essential for understanding its potential applications in various fields.

Formula: C₂₄H₂₉NO₂

InChI: InChI=1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)

InChI key: InChIKey=SLXTWXQUEZSSTJ-UHFFFAOYSA-N

SMILES: CC1=C(C2(CC2)C3=CC=C(C(O)=O)C=N3)C=C4C(=C1)C(C)(C)CCC4(C)C

Synonyms:

• 3-Pyridinecarboxylic acid, 6-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-
• 3-Pyridinecarboxylicacid,6-(1-(5,6,7,8-Tetrahydro-3,5,5,8,8-Pentamethyl-2-Nap
• 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydro-Naphthalen-2-Yl)-Cyclopropyl]-Nicotinic Acid (For R&D Only)
• 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid
• 6-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]- 3-Pyridinecarboxylic Acid
• Agn 192620
• Alrt 268
• Cd 3127
• Hthalenyl)Cyclopropyl)-
• Lg 100268
• Lg 268
• Lg100268
• Lgd 100268

LG100268

CAS: 153559-76-3

LG100268

Purity: ≥98%

Molecular weight: 363.49g/mol

Ref: 54-BUP21018

LG100268

CAS: 153559-76-3

LG100268 is a selective, and oral RXR agonist，inducing transcriptional activation in adipocytes; inhibits keratin 17 increases PD-L1 expression.

Formula: C₂₄H₂₉NO₂

Purity: 99.83%

Color and Shape: Solid

Molecular weight: 363.49

Ref: TM-T19703

LG 100268

Controlled Product

CAS: 153559-76-3

Applications LG 100268 is a potent RXR agonist for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM).
References Clyne, C., et al.: J. Biol. Chem., 277, 20591 (2002), Santen, R., et al.: J. Clin. Endocrinol. Metab., 87, 3007 (2002), Falender, A., et al.: Endocrinology, 144, 3598 (2003), Sablin, E., et al.: Mol. Cell., 11, 1575 (2003)

Formula: C₂₄H₂₉NO₂

Color and Shape: Neat

Molecular weight: 363.49

Ref: TR-L397650

LG 100268

CAS: 153559-76-3

LG 100268 is a synthetic retinoid that binds to Toll-like receptor 7 (TLR7) and inhibits the production of inflammatory cytokines. LG 100268 has been shown to be a novel TLR7 agonist that decreases the production of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α. This agent also has antiviral activity against HIV and cytotoxic effects on HL60 cells. LG 100268 may be useful for treating squamous cell carcinoma or other cancers in which TLR7 is involved in the pathogenesis. LG 100268 shows minimal toxicity at low doses and could serve as a model system for studying the molecular pathogenesis of cancer.

Formula: C₂₄H₂₉NO₂

Purity: Min. 95%

Molecular weight: 363.49 g/mol

Ref: 3D-FL24888