CAS 153631-20-0

Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2′-O-methyl-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

Description:

Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2′-O-methyl-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] is a complex nucleoside derivative characterized by its unique structural features that enhance its stability and reactivity. This compound contains a uridine base, which is a nucleoside composed of a ribose sugar and a uracil base, modified at the 5' position with a bis(4-methoxyphenyl)phenylmethyl group and at the 2' position with a methyl group. The presence of a phosphoramidite group at the 3' position, specifically a 2-cyanoethyl bis(1-methylethyl) phosphoramidite, indicates its potential use in oligonucleotide synthesis, as phosphoramidites are commonly employed as building blocks for the automated synthesis of DNA and RNA. The methoxyphenyl substituents may contribute to the compound's solubility and stability in various solvents, while the cyanoethyl group enhances the reactivity of the phosphoramidite moiety. Overall, this compound is significant in biochemical applications, particularly in the field of nucleic acid chemistry.

Formula: C₄₁H₅₁N₄O₉P

InChI: InChI=1S/C41H51N4O9P/c1-27(2)45(28(3)4)55(52-24-12-23-42)54-36-35(53-39(37(36)50-8)44-25-29(5)38(46)43-40(44)47)26-51-41(30-13-10-9-11-14-30,31-15-19-33(48-6)20-16-31)32-17-21-34(49-7)22-18-32/h9-11,13-22,25,27-28,35-37,39H,12,24,26H2,1-8H3,(H,43,46,47)/t35-,36-,37-,39-,55?/m1/s1

InChI key: InChIKey=GMJRPRHRYILEOK-VNZAIEIISA-N

SMILES: C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](OC)[C@@H](O1)N2C(=O)NC(=O)C(C)=C2)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5

Synonyms:

• Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2′-O-methyl-, 3′-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

2'-O-Methyl-5-methyl-U CEP

CAS: 153631-20-0

2'-O-Methyl-5-methyl-U CEP

Purity: 98%

Molecular weight: 774.84g/mol

Ref: 54-OR1001628

2'-O-Methyl-5-methyl-U CEP

CAS: 153631-20-0

2'-O-Methyl-5-methyl-U CEP is a useful organic compound for research related to life sciences. The catalog number is TNU1619 and the CAS number is 153631-20-0.

Formula: C₄₁H₅₁N₄O₉P

Color and Shape: Solid

Molecular weight: 774.84

Ref: TM-TNU1619

5'-O-DMT-2'-O-methyl-5-methyluridine 3'-CE phosphoramidite

CAS: 153631-20-0

5'-O-DMT-2'-O-methyl-5-methyluridine 3'-CE phosphoramidite is a novel antiviral and anticancer agent. It is a nucleoside analog that mimics the natural product from which it was synthesized, 2'-deoxycytidine 5'-O-DMT-3'-CE phosphoramidite. It has been shown to inhibit replication of DNA in vitro with an IC50 of less than 10 nM. 5'-O-DMT-2'-O-methyl-5-methyluridine 3'-CE phosphoramidite is also an inhibitor of human telomerase activity and can be used as a potential therapeutic for cancer treatment.

Formula: C₄₁H₅₁N₄O₉P

Purity: 90%

Color and Shape: White Powder

Molecular weight: 774.86 g/mol

Ref: 3D-PD09183

2′-O-Methyl-5-methyl-U CEP

CAS: 153631-20-0

Purity: 98%

Molecular weight: 774.34

Ref: 10-F556687