CAS 153660-03-8

SP-8-BR-CGMPS

Description:

SP-8-BR-CGMPS, with the CAS number 153660-03-8, is a synthetic compound that belongs to the class of cyclic guanosine monophosphate (cGMP) analogs. This substance is characterized by its ability to act as a potent and selective activator of soluble guanylate cyclase, an enzyme that plays a crucial role in the nitric oxide signaling pathway. The compound is often utilized in biochemical research to study various physiological processes, including vasodilation and neurotransmission. SP-8-BR-CGMPS is known for its stability and resistance to degradation, which makes it a valuable tool in experimental settings. Additionally, its structural modifications compared to natural cGMP enhance its biological activity and specificity. Researchers often explore its potential therapeutic applications, particularly in cardiovascular and neurobiological contexts. As with many synthetic compounds, handling SP-8-BR-CGMPS requires adherence to safety protocols to mitigate any potential hazards associated with its use in laboratory environments.

Formula: C₁₀H₁₀BrN₅NaO₆PS

Synonyms:

• Sp-8-Br-Cgmps Sodium Salt
• Sp-8-Bromoguanosine-3',5'-Cyclic Monophosphorothioate, Sodium Salt
• Guanosine 3',5'-Cyclic Monophosphorothioate, 8-Bromo-, Sp-Isomer, Sodium Salt
• 8-Br-Cgmps Na, Sp-Isomer
• 8-Bromoguanosine-3',5'-Cyclic Monophosphorothioate Sodium Salt, Spisomer
• 8-Bromoguanosine-3',5'-Cyclic Monophosphorothioate, Sp-Isomer Sodium Salt

Sp-8-Br-cGMPS

Controlled Product

CAS: 153660-03-8

Formula: C₁₀H₁₀BrN₅NaO₆PS

Color and Shape: Neat

Molecular weight: 462.149

Ref: TR-S683605

Sp-8-Br-cGMPS

CAS: 153660-03-8

Sp-8-Br-cGMPS, an analogue of cGMP, acts as an agonist for cGMP gated cation channels (CNG channels) with an EC50 of 106.5 μM. While Sp-8-Br-cGMPS can induce currents, it does not stabilize channel open states as effectively as a full agonist.

Formula: C₁₀H₁₁BrN₅O₆PS

Color and Shape: Solid

Molecular weight: 440.17

Ref: TM-T88734