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CAS 153832-38-3

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Ertapenem disodium

Description:
Ertapenem disodium is a broad-spectrum, beta-lactam antibiotic belonging to the carbapenem class, primarily used for the treatment of various bacterial infections. It exhibits a high degree of stability against many beta-lactamases, making it effective against a wide range of Gram-positive and Gram-negative bacteria. The disodium salt form enhances its solubility in aqueous solutions, facilitating intravenous administration. Ertapenem is characterized by its ability to penetrate bacterial cell walls effectively, leading to the inhibition of cell wall synthesis, which is crucial for bacterial growth and replication. It is typically administered in a clinical setting for infections such as intra-abdominal infections, skin and soft tissue infections, and community-acquired pneumonia. The pharmacokinetics of ertapenem indicate a long half-life, allowing for once-daily dosing. However, it is important to note that ertapenem is not effective against certain organisms, including Pseudomonas aeruginosa and Enterococcus species. As with all antibiotics, appropriate use is essential to minimize the risk of resistance development.
Formula:C22H23N3Na2O7S
InChI:InChI=1/C22H25N3O7S.2Na/c1-9-16-15(10(2)26)20(28)25(16)17(22(31)32)18(9)33-13-7-14(23-8-13)19(27)24-12-5-3-4-11(6-12)21(29)30;;/h3-6,9-10,13-16,23,26H,7-8H2,1-2H3,(H,24,27)(H,29,30)(H,31,32);;/q;2*+1/p-2/t9-,10-,13+,14+,15-,16-;;/m1../s1
SMILES:CC1C2C(C(C)O)C(=O)N2C(=C1SC1CC(C(=Nc2cccc(c2)C(=O)O)O)NC1)C(=O)O.[Na].[Na]
Synonyms:
  • disodium (4R,5R,6S)-3-[(3S,5S)-5-[(3-carboxylatophenyl)carbamoyl]pyrro lidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  • 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((3S,5S)-5-(((3-ca rboxyphenyl)amino)carbonyl)-3-pyrrolidinyl)thio)-6-((1R)-1-hydroxyethy l)-4-methyl-7-oxo-, monosodium salt, (4R,5S,6S)-
  • disodium (4R,5S,6S)-3-({(3S,5S)-5-[(3-carboxylatophenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
  • disodium (4R,5R,6S)-3-[(3S,5S)-5-[(3-carboxylatophenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
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Found 3 products.