CAS 154-42-7

Thioguanine

Description:

Thioguanine is a synthetic purine analog and an antimetabolite used primarily in the treatment of certain types of leukemia and other malignancies. Its chemical structure features a thiol group, which distinguishes it from guanine, a naturally occurring nucleobase. The compound is known for its ability to interfere with nucleic acid synthesis, thereby inhibiting cell proliferation, particularly in rapidly dividing cancer cells. Thioguanine is typically administered orally and is metabolized in the liver, where it is converted into active metabolites that exert cytotoxic effects. It is important to monitor patients for potential side effects, including myelosuppression, hepatotoxicity, and gastrointestinal disturbances. Additionally, thioguanine can exhibit interactions with other medications, necessitating careful management in combination therapies. Due to its mechanism of action, thioguanine is classified as an antineoplastic agent and is often used in conjunction with other chemotherapeutic agents to enhance therapeutic efficacy. Its use is guided by specific dosing regimens and patient response, making it a critical component in the management of certain hematological cancers.

Formula: C₅H₅N₅S

InChI: InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

InChI key: InChIKey=WYWHKKSPHMUBEB-UHFFFAOYSA-N

SMILES: S=C1C2=C(NC(N)=N1)N=CN2

Synonyms:

• 2-Amino-1,7-Dihydro-6H-Purin-6-Thion
• 2-Amino-1,7-Dihydro-6H-Purine-6-Thion
• 2-Amino-1,9-dihydro-6H-purine-6-thione
• 2-Amino-1,9-dihydro-purine-6-thione
• 2-Amino-1H-purine-6(7H)-thione
• 2-Amino-3,7-dihydropurine-6-thione
• 2-Amino-6-Mercaptopurine
• 2-Amino-6-Mercaptopurine Crystalline
• 2-Amino-6-purinethiol (6-Thioguanine)
• 2-Amino-7H-purine-6-thiol
• 2-Amino-9H-purine-6(1H)-thione
• 2-Amino-9H-purine-6-thiol
• 2-Aminopurine-6(1H)-Thione
• 2-Aminopurine-6-thiol
• 2-amino-3,5-dihydro-6H-purine-6-thione
• 2-amino-3,7-dihydro-6H-purine-6-thione
• 2-amino-6-mercaptopurine (50X)*gamma-irradiated C
• 2-amino-7H-purine-6-thiolate
• 6-Mercaptoguanine
• 6-Tg
• 6-Thioguanine
• 6H-Purine-6-thione, 2-amino-1,7-dihydro-
• 6H-Purine-6-thione, 2-amino-1,9-dihydro-
• Guanine, thio-
• Lanvis
• Nsc 752
• Nsc 76504
• Purine-6(1H)-thione, 2,3-dihydro-2-imino-
• Purine-6(1H)-thione, 2-amino-
• Purine-6-thiol, 2-amino-
• Tabloid
• Thioguanine
• Thioguanine Tabloid
• Tioguanin
• Tioguanina
• Tioguanine

6-Thioguanine

CAS: 154-42-7

Formula: C₅H₅N₅S

Purity: >95.0%(HPLC)

Color and Shape: Light orange to Yellow to Green powder to crystal

Molecular weight: 167.19

Ref: 3B-T0212

6-Thioguanine, 98%

CAS: 154-42-7

6-Thioguanine acts as an antineoplastic and purine antimetabolite. It is also useful as an inhibition of stimulated expression of TNF-related apoptosis-inducing ligand (TRAIL) protein. It is involved in the treatment of acute leukemias and Psoriasis. Further, it is used for the treatment of ulcerati

Formula: C₅H₅N₅S

Purity: 98%

Color and Shape: White to pale cream or pale yellow or pale yellow-green, Powder

Molecular weight: 167.19

Ref: 02-B21280

Thioguanine

CAS: 154-42-7

Color and Shape: Neat

Ref: 61-FOR0865.00

Mercaptopurine impurity standard

CAS: 154-42-7, 6112-76-1, 68-94-0, 73-24-5

Mercaptopurine impurity standard

Color and Shape: Yellow

Ref: 47-762

Tioguanine

CAS: 154-42-7

Tioguanine

Formula: C₅H₅N₅S

Purity: 98.8%

Color and Shape: Light Yellow

Molecular weight: 167.02657

Ref: 47-878

Thioguanine

CAS: 154-42-7

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

Formula: C₅H₅N₅S(anhydrous)

Color and Shape: Pale Yellow Crystalline Powder

Molecular weight: 167.02657

Ref: 45-1660000

6-Thioguanine

CAS: 154-42-7

Formula: C₅H₅N₅S

Molecular weight: 167.19

Ref: 4Z-G-2450

6-Thioguanine

CAS: 154-42-7

Formula: C₅H₅N₅S

Purity: ≥ 96.0% (dried basis)

Color and Shape: White to off-white or light yellow-green powder

Molecular weight: 167.19

Ref: 7W-GP0033

6-Thioguanine

CAS: 154-42-7

6-Thioguanine

Purity: ≥98%

Molecular weight: 167.19g/mol

Ref: 54-BUP14765

2-Amino-6-purinethiol

CAS: 154-42-7

2-Amino-6-purinethiol

Formula: C₅H₅N₅S

Purity: ≥95%

Color and Shape: Pale Yellow Powder

Molecular weight: 167.19g/mol

Ref: 54-OR4016

Thioguanine

Controlled Product

CAS: 154-42-7

Formula: C₅H₅N₅S

Color and Shape: Neat

Molecular weight: 167.19

Ref: 86-MM0865.00

6-Thioguanine

CAS: 154-42-7

6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

Formula: C₅H₅N₅S

Purity: 98.34% - >99.99%

Color and Shape: Odorless Or Almost Odorless Pale Yellow Crystalline Powder

Molecular weight: 167.19

Ref: TM-T3089

2-Amino-6-mercaptopurine

Controlled Product

CAS: 154-42-7

Applications The compound produced dose-dependent inhibition of stimulated expression of TRAIL protein.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Thomas, C.W., et al.: J. Pharmacol. Exp. Ther., 312, 537 (2005),

Formula: C₅H₅N₅S

Color and Shape: Light Yellow

Molecular weight: 167.19

Ref: TR-A611830

6-Thioguanine

CAS: 154-42-7

Phosphoribosyltransferase inhibitor; photocytotoxic

Formula: C₅H₅N₅S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 167.19 g/mol

Ref: 3D-FT06261

6-Thioguanine - Bio-X ™

CAS: 154-42-7

6-Thioguanine is a purine analog used in the therapy for leukemia and for remission consolidation in patients with acute nonlymphocytic anemia. This drug also has antimetabolite action. It replaces guanine during DNA replication. This substitution disrupts the accurate pairing of DNA bases, leading to errors in DNA replication and hinders cell division.

Formula: C₅H₅N₅S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 167.19 g/mol

Ref: 3D-BT166463

2-Amino-1,7-dihydro-6H-purine-6-thione

CAS: 154-42-7

Formula: C₅H₅N₅S

Purity: 95%

Color and Shape: Solid

Molecular weight: 167.19

Ref: 10-F358091