CAS 154039-60-8

Marimastat

Description:

Marimastat is a synthetic compound classified as a matrix metalloproteinase (MMP) inhibitor, primarily developed for therapeutic applications in cancer treatment and other diseases characterized by excessive tissue remodeling. It functions by inhibiting the activity of MMPs, enzymes that play a crucial role in the degradation of extracellular matrix components, thereby influencing tumor invasion and metastasis. Marimastat is typically administered orally and has been investigated in various clinical trials for its efficacy in treating solid tumors, including pancreatic and breast cancers. The compound exhibits a relatively low molecular weight and is characterized by its specific binding affinity to the active sites of MMPs. Its pharmacokinetic properties include moderate absorption and a variable half-life, which can affect dosing regimens. While it has shown promise in preclinical studies, clinical outcomes have been mixed, leading to ongoing research to better understand its therapeutic potential and optimize its use in oncology. As with many investigational drugs, safety and side effect profiles are critical considerations in its development and application.

Formula: C₁₅H₂₉N₃O₅

InChI: InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1

InChI key: InChIKey=OCSMOTCMPXTDND-OUAUKWLOSA-N

SMILES: [C@H](C(N[C@H](C(NC)=O)[C@@](C)(C)C)=O)([C@@H](C(NO)=O)O)CC(C)C

Synonyms:

• (2S,3R)-N4-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)butanediamide
• Butanediamide, N4-[2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)-, [2S-[N4(R*),2R*,3S*]]-
• Butanediamide, N4-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-N1,2-dihydroxy-3-(2-methylpropyl)-, (2S,3R)-
• BB 2516
• Marimastat

Marimastat

CAS: 154039-60-8

Formula: C₁₅H₂₉N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 331.4079

Ref: IN-DA007XSA

Marimastat

CAS: 154039-60-8

Marimastat

Purity: ≥95%

Molecular weight: 331.41g/mol

Ref: 54-BUP03253

Marimastat

CAS: 154039-60-8

Formula: C₁₅H₂₉N₃O₅

Molecular weight: 331.41

Ref: 7W-GP3364

Marimastat

CAS: 154039-60-8

Marimastat (BB2516) (BB-2516) is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor.

Formula: C₁₅H₂₉N₃O₅

Purity: 97.46% - 98.11%

Color and Shape: Solid

Molecular weight: 331.41

Ref: TM-T6885

Marimastat

Controlled Product

CAS: 154039-60-8

Formula: C₁₅H₂₉N₃O₅

Color and Shape: Neat

Molecular weight: 331.408

Ref: TR-M197240

Marimastat

CAS: 154039-60-8

Broad spectrum MMP inhibitor

Formula: C₁₅H₂₉N₃O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 331.41 g/mol

Ref: 3D-FM161188