CAS 154044-57-2

Docetaxel Hydroxy-tert-butyl-carbamate

Description:

Docetaxel Hydroxy-tert-butyl-carbamate, with the CAS number 154044-57-2, is a derivative of the chemotherapeutic agent docetaxel, which is primarily used in cancer treatment. This compound features a hydroxy-tert-butyl-carbamate moiety that enhances its solubility and stability, potentially improving its pharmacokinetic properties. The structure typically includes a taxane core, which is essential for its mechanism of action, involving the inhibition of microtubule depolymerization, thereby disrupting mitotic spindle formation and leading to cell cycle arrest in cancer cells. The hydroxy-tert-butyl-carbamate modification may also influence the compound's bioavailability and therapeutic efficacy. As with many chemotherapeutic agents, docetaxel derivatives are subject to extensive research to optimize their effectiveness and minimize side effects. The compound's characteristics, including its molecular weight, solubility, and stability, are critical for its application in clinical settings, and ongoing studies aim to elucidate its full potential in cancer therapy.

Formula: C₄₃H₅₃NO₁₅

InChI: InChI=1/C43H53NO15/c1-22-26(56-37(52)32(49)30(24-14-10-8-11-15-24)44-38(53)59-39(3,4)20-45)19-43(54)35(57-36(51)25-16-12-9-13-17-25)33-41(7,34(50)31(48)29(22)40(43,5)6)27(47)18-28-42(33,21-55-28)58-23(2)46/h8-17,26-28,30-33,35,45,47-49,54H,18-21H2,1-7H3,(H,44,53)/t26?,27-,28+,30-,31+,32?,33-,35?,41+,42-,43+/m0/s1

Synonyms:

• Docetaxel Metabolite 2, Hydroxy Taxotere, RPR 104952

Docetaxel Metabolite M2

CAS: 154044-57-2

Formula: C₄₃H₅₃NO₁₅

Molecular weight: 823.90

Ref: 4Z-D-1915

Docetaxel Hydroxy tert-Butylcarbamate

Controlled Product

CAS: 154044-57-2

Applications The main metabolite of Docetaxel (D494420), an antineoplastic.
References Commercon, A., et al.: Tetrahedron, 50, 34, 10289 (1994)

Formula: C₄₃H₅₃NO₁₅

Color and Shape: White To Off-White

Molecular weight: 823.88

Ref: TR-D494425

Docetaxel Hydroxy tert-Butylcarbamate-d6

Controlled Product

CAS: 154044-57-2

Applications Docetaxel Hydroxy tert-Butylcarbamate-d6 is the labeled analogue of Docetaxel Hydroxy tert-Butylcarbamate (D494425), the main metabolite of Docetaxel (D494420), an antineoplastic.
References Commercon, A., et al.: Tetrahedron, 50, 34, 10289 (1994);

Formula: C₄₃H₄₇D₆NO₁₅

Color and Shape: Neat

Molecular weight: 829.92

Ref: TR-D494427