CAS 1541172-75-1

(S)-N-((S)-1-(((2R,4S)-1,2-Dihydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

Description:

The chemical substance with the name "(S)-N-((S)-1-(((2R,4S)-1,2-Dihydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide" and CAS number "1541172-75-1" is a complex organic compound characterized by its chiral centers and multiple functional groups. It features a combination of amide linkages, hydroxyl groups, and a morpholino moiety, which suggests potential biological activity, possibly as a pharmaceutical agent. The presence of multiple stereocenters indicates that the compound may exhibit stereospecific properties, influencing its interaction with biological targets. Additionally, the structure suggests a relatively high molecular weight and complexity, which may affect its solubility and pharmacokinetic properties. Such compounds are often investigated for their potential therapeutic applications, particularly in fields like medicinal chemistry and drug development. However, specific characteristics such as melting point, solubility, and biological activity would require empirical data for precise evaluation.

Formula: C₄₀H₅₉N₅O₈

Synonyms:

• (S)-N-((S)-1-(((2R,4S)-1,2-Dihydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pe
• PR-519
• Kyprolis Impurity V
• L-Phenylalaninamide, (αS)-α-[[2-(4-morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S,3R)-3,4-dihydroxy-3-methyl-1-(2-methylpropyl)-2-oxobutyl]-
• (S)-N-((S)-1-(((2R,4S)-1,2-Dihydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

Carfilzomib Impurity 2 (RSSSS)

CAS: 1541172-75-1

Formula: C₄₀H₅₉N₅O₈

Molecular weight: 737.94

Ref: ST-EA-CP-C153002

(S)-N-((S)-1-(((2R,4S)-1,2-Dihydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

CAS: 1541172-75-1

(S)-N-((S)-1-(((2R,4S)-1,2-Dihydroxy-2,6-dimethyl-3-oxoheptan-4-yl)amino)-1-oxo-3-phenylpropan-2-yl)-4-methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamide

Purity: 95%

Molecular weight: 737.93g/mol

Ref: 54-OR1075595

Carfilzomib Impurity 2 (PR-519M16, Carfilzomib (2R,4S)-Diol)

CAS: 1541172-75-1

Formula: C₄₀H₅₉N₅O₈

Color and Shape: White To Off-White Solid

Molecular weight: 737.94

Ref: 4Z-C-121005

Carfilzomib (2R,4S)-Diol

Controlled Product

CAS: 1541172-75-1

Applications Carfilzomib (2R,4S)-Diol is a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.
References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);

Formula: C₄₀H₅₉N₅O₈

Color and Shape: Neat

Molecular weight: 737.93

Ref: TR-C183470

Carfilzomib (2S,4S)-Diol Hydrochloride

Controlled Product

CAS: 1396006-50-0, 1541172-75-1, 2049025-83-2

Formula: C₄₀H₅₉N₅O₈•HCl

Color and Shape: Neat

Molecular weight: 774.39

Ref: TR-C183498

Carfilzomib (2R,4S)-diol

CAS: 1541172-75-1

Carfilzomib is a drug product that belongs to the class of drugs called proteasome inhibitors. It has been used in the treatment of multiple myeloma, and is also being studied for use in other diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Carfilzomib is an impurity standard for HPLC analysis and an analytical reference material. It is also used as a pharmacopoeia reference material. Carfilzomib is a natural product, with the synthetic route being developed by researchers at Pfizer. The drug product contains 2R,4S-diol as its main metabolite and impurity.

Formula: C₄₀H₅₉N₅O₈

Purity: Min. 95%

Molecular weight: 737.90 g/mol

Ref: 3D-RLC17275