CAS 154226-60-5

6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione,1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)-

Description:

6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)- is a complex organic compound characterized by its bicyclic structure, which includes both nitrogen and oxygen heteroatoms. The presence of a bicyclic framework contributes to its unique chemical properties, such as potential reactivity and stability under various conditions. The compound features a hydroxyl group, which can participate in hydrogen bonding, enhancing its solubility in polar solvents. Additionally, the stereochemistry indicated by the (1R,4R,5S) configuration suggests specific spatial arrangements of its substituents, which can influence its biological activity and interactions with other molecules. This compound may exhibit interesting pharmacological properties, making it a subject of interest in medicinal chemistry. Its CAS number, 154226-60-5, allows for easy identification and retrieval of information regarding its synthesis, applications, and safety data in chemical databases. Overall, this compound exemplifies the complexity and diversity found in organic chemistry, particularly in the design of bioactive molecules.

Formula: C₁₀H₁₅NO₄

Synonyms:

• 6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione,1-(1-hydroxy-2-methylpropyl)-4-methyl-, [1R-[1a(S*),4b,5a]]-
• (-)-Omuralide
• clasto-Lactacystin b-lactone
• b-Clastolactacystin
• b-Lactacystin

Clasto-Lactacystin β-lactone

CAS: 154226-60-5

Formula: C₉H₁₃NO₄

Color and Shape: Solid

Molecular weight: 199.2038

Ref: IN-DA001OEF

clasto-Lactacystin β-lactone

CAS: 154226-60-5

Molecular weight: 213.2

Ref: 7W-GA9931

clasto-Lactacystin b-lactone

CAS: 154226-60-5

Formula: C₁₀H₁₅NO₄

Molecular weight: 213.23

Ref: 7W-GK6045

Clasto-lactacystin(Omuralide)

Controlled Product

CAS: 154226-60-5

Applications A cell permeable, irreversible proteasome inhibitor. It is 20-fold more potent than Lactacystin. Lactacytstin spontaneously converts to clasto-lactacystin in biological systems. Clasto-lactacystin is the only cell permeable form of lactacystin. Induces neurite growth and inhibits cell cycle progression similar to lactacytin.
References Craiu, A., et al.: J. Biol. Chem., 272, 13437 (1997), Dick, G.L.R., et al.: J. Biol. Chem., 272, 182 (1997), Fenteany, G. and Schreiber, S.: J. Biol. Chem., 273, 8545 (1998), Corey, E.J., et al.: J.A.C.S., 120, 2330 (1998)

Formula: C₁₀H₁₅NO₄

Color and Shape: Neat

Molecular weight: 213.23

Ref: TR-C562500