CAS 154229-18-2

Abiraterone acetate

Description:

Abiraterone acetate is a synthetic steroid and a selective inhibitor of the enzyme CYP17A1, which is crucial in the biosynthesis of androgens. It is primarily used in the treatment of metastatic castration-resistant prostate cancer. The compound is characterized by its ability to reduce androgen production, thereby inhibiting tumor growth that is driven by these hormones. Abiraterone acetate is administered orally and is often used in combination with prednisone to mitigate potential side effects related to adrenal insufficiency. The substance is a white to off-white crystalline powder, and its solubility is limited in water but more favorable in organic solvents. Its pharmacokinetics indicate that it undergoes extensive metabolism, primarily in the liver, and has a relatively long half-life, allowing for once-daily dosing. Common side effects may include hypertension, hypokalemia, and liver function abnormalities. Overall, Abiraterone acetate represents a significant advancement in targeted cancer therapy, particularly for patients with advanced prostate cancer.

Formula: C₂₆H₃₃NO₂

InChI: InChI=1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1

InChI key: InChIKey=UVIQSJCZCSLXRZ-UBUQANBQSA-N

SMILES: C[C@@]12[C@]([C@]3([C@](CC1)([C@]4(C)C(=CC3)C[C@@H](OC(C)=O)CC4)[H])[H])(CC=C2C=5C=CC=NC5)[H]

Synonyms:

• (3)-17-(3-Pyridinyl)androsta-5,16-dien-3-ol Acetate (Ester)
• (3Beta,8Xi,9Xi,14Xi)-17-(Pyridin-3-Yl)Androsta-5,16-Dien-3-Yl Acetate
• (3β)-17-(3-Pyridinyl)androsta-5,16-dien-3-yl acetate
• Abiraterone Acetate
• Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, acetate (ester), (3β)-
• Cb 7630
• Zytiga

Abiraterone Acetate

CAS: 154229-18-2

Formula: C₂₆H₃₃NO₂

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 391.56

Ref: 3B-A2891

Abiraterone Acetate

CAS: 154229-18-2

Adrenal cortical hormones and their derivatives nesoi

Formula: C₂₆H₃₃NO₂

Color and Shape: White Crystalline Powder

Molecular weight: 391.25113

Ref: 45-1000818

ABIRATERONE ACETATE

CAS: 154229-18-2

Formula: C₂₆H₃₃NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 391.5457

Ref: IN-DA00362K

Abiraterone Acetate

CAS: 154229-18-2

Abiraterone Acetate (CB7630) is an androstene derivative that inhibits steroid 17-alpha-hydroxylase and is used as an antineoplastic agent.

Formula: C₂₆H₃₃NO₂

Purity: 99.69% - 99.82%

Color and Shape: Solid

Molecular weight: 391.55

Ref: TM-T6215

Abiraterone Acetate

CAS: 154229-18-2

Formula: C₂₆H₃₃NO₂

Color and Shape: White To Off-White Solid

Molecular weight: 391.56

Ref: 4Z-A-827

Abiraterone acetate

CAS: 154229-18-2

Abiraterone acetate

Purity: 98%

Molecular weight: 391.55g/mol

Ref: 54-OR1030317

Abiraterone Acetate

CAS: 154229-18-2

Abiraterone Acetate

Purity: ≥98%

Molecular weight: 391.55g/mol

Ref: 54-BUP14483

Abiraterone acetate

CAS: 154229-18-2

Formula: C₂₆H₃₃NO₂

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 391.55

Ref: 7W-GP3228

Abiraterone Acetate

Controlled Product

CAS: 154229-18-2

Formula: C₂₆H₃₃NO₂

Color and Shape: Neat

Molecular weight: 391.55

Ref: 86-MM3504.00

Abiraterone Acetate

Controlled Product

CAS: 154229-18-2

Applications Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450 (17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
References Denis, L., et al.: Cancer, 72, 3888 (1993), Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995), Denmeade, S., et al.: Nat. Rev., 2, 389(2002), Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005),

Formula: C₂₆H₃₃NO₂

Color and Shape: Neat

Molecular weight: 391.55

Ref: TR-A108500

Abiraterone Acetate-d4

Controlled Product

CAS: 154229-18-2

Applications Labelled Abiraterone acetate is a novel steroidal inhibitor of human Cytochrome P450(17α-Hydroxylase-C17,20-lyase): potential agent for the treatment of prostatic cancer.
References Denis, L., et al.: Cancer, 72, 3888 (1993), Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995), Denmeade, S., et al.: Nat. Rev., 2, 389(2002), Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005),

Formula: C₂₆H₂₉D₄NO₂

Color and Shape: Neat

Molecular weight: 395.57

Ref: TR-A108502

Abiraterone acetate

Controlled Product

CAS: 154229-18-2

CYP17 enzyme inhibitor

Formula: C₂₆H₃₃NO₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 391.55 g/mol

Ref: 3D-FA16106

Abiraterone acetate - Bio-X ™

Controlled Product

CAS: 154229-18-2

Abiraterone is an antiandrogen drug used in the treatment of metastatic prostate cancer. It is a derivative of steroidal progesterone. This drug inhibits the enzyme CYP17 irreversibly, thus inhibiting the synthesis of androgen. It specifically inhibits the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone to decrease serum levels of testosterone and other androgens.

Formula: C₂₆H₃₃NO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 391.55 g/mol

Ref: 3D-BA164133

Abiraterone acetate

CAS: 154229-18-2

Formula: C₂₆H₃₃NO₂

Purity: 95.0%

Color and Shape: White to off-white powder

Molecular weight: 391.555

Ref: 10-F213789

Chlorobutoxy Abiraterone-d8

Controlled Product

CAS: 154229-18-2

Formula: C₂₈D₈H₃₀ClNO

Color and Shape: Neat

Molecular weight: 448.11

Ref: TR-C283812

3-Epiabiraterone-d4 Acetate

Controlled Product

CAS: 154229-18-2

Formula: C₂₆H₂₉D₄NO₂

Color and Shape: Neat

Molecular weight: 395.57

Ref: TR-E577002