CAS 154229-19-3

Abiraterone

Description:

Abiraterone is a synthetic organic compound primarily used in the treatment of prostate cancer. It functions as a selective inhibitor of the enzyme CYP17A1, which is crucial in the biosynthesis of androgens, including testosterone. By inhibiting this enzyme, Abiraterone effectively reduces androgen levels, thereby slowing the growth of androgen-dependent tumors. The compound is typically administered in the form of its acetate salt, Abiraterone acetate, which is more soluble and bioavailable. Abiraterone is characterized by its molecular formula, which reflects its complex structure, and it exhibits a moderate to high lipophilicity, allowing it to penetrate cellular membranes effectively. The drug is often used in combination with corticosteroids to mitigate potential side effects related to adrenal insufficiency. Common side effects include fatigue, hypertension, and electrolyte imbalances. Overall, Abiraterone represents a significant advancement in targeted cancer therapy, particularly for patients with metastatic castration-resistant prostate cancer.

Formula: C₂₄H₃₁NO

InChI: InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1

InChI key: InChIKey=GZOSMCIZMLWJML-VJLLXTKPSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC=C2C=5C=CC=NC5)[H]

Synonyms:

• (3Beta)-17-(Pyridin-3-Yl)Androsta-5,16-Dien-3-Ol
• (3b)-17-(3-pyridinyl)-Androsta-5,16-dien-3-ol
• 17-(3-Pyridinyl)-androsta-5,16-dien-3β-ol
• 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol
• Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, (3β)-
• Cb 7598
• Abiraterone

Abiraterone

CAS: 154229-19-3

Formula: C₂₄H₃₁NO

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 349.52

Ref: 3B-A2868

Abiraterone

CAS: 154229-19-3

Abiraterone (CB-7598) (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50: 4 nM).

Formula: C₂₄H₃₁NO

Purity: 99.18% - 99.93%

Color and Shape: White Solid

Molecular weight: 349.51

Ref: TM-T6216

(1S,2R,5S,10R,11S,15S)-2,15-dimethyl-14-(pyridin-3-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-7,13-dien-5-ol

CAS: 154229-19-3

Formula: C₂₄H₃₁NO

Purity: 99%

Color and Shape: Solid

Molecular weight: 349.5090

Ref: IN-DA007GBE

Abiraterone

CAS: 154229-19-3

Abiraterone

Purity: ≥98%

Molecular weight: 349.51g/mol

Ref: 54-BUP13272

Abiraterone

CAS: 154229-19-3

Abiraterone

Purity: 98%

Molecular weight: 349.52g/mol

Ref: 54-OR1030342

Abiraterone

CAS: 154229-19-3

Formula: C₂₄H₃₁NO

Color and Shape: White To Off-White Solid

Molecular weight: 349.52

Ref: 4Z-A-822

Abiraterone

Controlled Product

CAS: 154229-19-3

Formula: C₂₄H₃₁NO

Color and Shape: Neat

Molecular weight: 349.51

Ref: 86-MM3294.00

Abiraterone

CAS: 154229-19-3

Formula: C₂₄H₃₁NO

Purity: ≥ 99.0%

Color and Shape: Off-white powder

Molecular weight: 349.51

Ref: 7W-GP8507

Abiraterone Sulfate Sodium Salt

CAS: 154229-19-3

Stability Hygroscopic
Applications Abiraterone Sulfate is an analogue of Abiraterone (A108490).

Formula: C₂₄H₃₀NO₄S·Na

Color and Shape: Neat

Molecular weight: 451.55

Ref: TR-A108515

Abiraterone

Controlled Product

CAS: 154229-19-3

Applications Abiraterone is a steroidal cytochrome P 450 17α-hydroxylase-17,20-lyase inhibitor (CYP17), is currently undergoing phase II clinical trials as a potential drug for the treatment of androgen-dependent prostate cancer.
References Denis, L., et al.: Cancer, 72, 3888 (1993); Potter, G.A., et al.: J. Med. Chem., 38, 2463 (1995); Denmeade, S., et al.: Nat. Rev., 2, 389 (2002); Scher, H., et al.: J. Clin. Oncol., 23, 8253 (2005);

Formula: C₂₄H₃₁NO

Color and Shape: White

Molecular weight: 349.51

Ref: TR-A108490

Abiraterone N-Oxide Sulfate Sodium Salt

CAS: 154229-19-3, 1993430-24-2

Applications Abiraterone N-Oxide Sulfate is an analogue of Abiraterone (A108490).

Formula: C₂₄H₃₀NO₅S·Na

Color and Shape: Neat

Molecular weight: 467.5535

Ref: TR-A108520

Abiraterone

Controlled Product

CAS: 154229-19-3

CYP17 enzyme inhibitor

Formula: C₂₄H₃₁NO

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 349.51 g/mol

Ref: 3D-FA16899

Apremilast EP Impurity E

CAS: 154229-19-3

Formula: C22H24N2O7S

Molecular weight: 460.5

Ref: ML-APM05

(3-β)-17-(3-Pyridinyl)-androsta-5,16-dien-3-ol

CAS: 154229-19-3

Formula: C₂₄H₃₁NO

Purity: 99%

Color and Shape: Solid

Molecular weight: 349.518

Ref: 10-F222701

Abiraterone - Bio-X ™

Controlled Product

CAS: 154229-19-3

Abiraterone is an anti-cancer drug that has been shown to be effective in treating prostate cancer. It works by blocking the production of testosterone by inhibiting androgen synthesis. Abiraterone does this by inhibiting CYP17A1, which converts cholesterol into pregnenolone, and then into progesterone and testosterone. Furthermore, it binds to the enzyme steroid 5-alpha reductase, which converts testosterone into dihydrotestosterone (DHT). Abiraterone is usually a last resort for patients who have stopped responding to other lines of hormone therapies, which is known as second-line therapy.

Formula: C₂₄H₃₁NO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 349.51 g/mol

Ref: 3D-BA164060