CAS 154303-05-6

ECHISTATIN

Description:

Echistatin is a naturally occurring peptide derived from the venom of the Echis carinatus snake, known for its potent anticoagulant properties. It functions primarily as a selective inhibitor of integrins, which are proteins that facilitate cell adhesion and signaling. This characteristic makes echistatin a valuable tool in biomedical research, particularly in studies related to cancer metastasis and thrombosis. The substance exhibits a high affinity for the αvβ3 integrin, which is often overexpressed in various tumors, thereby influencing angiogenesis and tumor growth. Echistatin is typically characterized by its small size and specific amino acid sequence, which contributes to its biological activity. Additionally, it has been studied for its potential therapeutic applications, including the development of anti-cancer drugs and treatments for cardiovascular diseases. As with many peptides, stability and delivery methods are critical factors in its application, necessitating further research to optimize its use in clinical settings.

Synonyms:

• M.W. 5417.05 C217H341N71O74S9 (Disulfide bonds between Cys2 and Cys11/Cys7 and Cys32/ Cys8 and Cys37/Cys20 and Cys39)

Echistatin

CAS: 154303-05-6

Echistatin is a 49-amino acid polypeptide from the venom of the saw-scaled viper, Echis carinatus. The peptide containing an RGD motif binds to the glycoprotein IIb/IIIa receptor on the platelet and is a potent competitive inhibitor of ADPstimulated platelet aggregation mediated by fibrinogen and other factors. Furthermore, echistatin effectively inhibits osteoclastic bone resorption in vitro and in vivo.

Formula: C₂₁₇H₃₄₁N₇₁O₇₄S₉

Purity: > 90%

Color and Shape: Whitish Powder

Molecular weight: 5417.12

Ref: 01-4030571

Echistatin

CAS: 154303-05-6

Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).

Formula: C₂₁₇H₃₄₁N₇₁O₇₄S₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 5417.1

Ref: TM-TP2098

Echistatin

CAS: 154303-05-6

Echistatin is a natural product isolated from the venom of the snake Echis carinatus. It is an inhibitor of protein synthesis that binds to the integrin receptor and blocks the binding of extracellular matrix proteins, leading to cell death. Echistatin has been shown to inhibit the proliferation of human osteosarcoma cells in vitro and induce neuronal death in vivo. In addition, it has been shown to be effective against human breast cancer cells that express high levels of integrins. The disulfide bond in echistatin may represent a potential anticancer agent due to its ability to form covalent bonds with other molecules such as DNA, RNA, or proteins.

Formula: C₂₁₇H₃₄₁N₇₁O₇₄S₉

Purity: Min. 95%

Molecular weight: 5,417.14 g/mol

Ref: 3D-ECT-3760-PI

Echistatin α1 isoform

CAS: 154303-05-6

Antagonization of αVβ3 integrin. Inhibition of cell proliferation, migration, invasion, and adhesion of αVβ3 expressing cells.

Ref: 3D-PP51166

Echistatin

CAS: 154303-05-6

Echistatin is a monoclonal antibody that binds to the Fc receptor on human cells, which blocks the interaction of fibrinogen with integrin receptors. It has shown potential as an anticancer agent in cell cultures and animal models. Echistatin may be used in combination with other drugs, such as cyclosporin A, to inhibit tumor growth. Echistatin also inhibits the proliferation of human osteosarcoma cells, suggesting that it may be useful for treating cancer of the bone.

Formula: C₂₁₇H₃₄₁N₇₁O₇₄S₉

Purity: Min. 95%

Molecular weight: 5,417.06 g/mol

Ref: 3D-FE110368