CAS 154323-57-6

Almotriptan

Description:

Almotriptan is a selective serotonin receptor agonist primarily used in the treatment of migraine headaches. It belongs to the triptan class of medications, which are designed to alleviate migraine symptoms by targeting serotonin receptors in the brain, specifically the 5-HT_1B and 5-HT_1D subtypes. Almotriptan is characterized by its ability to induce vasoconstriction of cranial blood vessels, thereby counteracting the vasodilation that occurs during a migraine attack. The chemical structure of almotriptan includes a sulfonamide group, which contributes to its pharmacological properties. It is typically administered orally and is known for its relatively favorable side effect profile compared to other triptans. Common side effects may include dizziness, fatigue, and nausea, but serious adverse effects are rare. Almotriptan is metabolized primarily in the liver, and its pharmacokinetics allow for a rapid onset of action, making it effective for acute migraine relief. Overall, almotriptan represents a valuable option in the management of migraine disorders.

Formula: C₁₇H₂₅N₃O₂S

InChI: InChI=1S/C17H25N3O2S/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3

InChI key: InChIKey=WKEMJKQOLOHJLZ-UHFFFAOYSA-N

SMILES: C(CN(C)C)C=1C=2C(NC1)=CC=C(CS(=O)(=O)N3CCCC3)C2

Synonyms:

• 1-[[3-(2-Dimethylaminoethyl)-5-Indolyl]Methanesulphonyl]Pyrrolidine Malate
• 1-[[[2-(Dimethyl-Amino)Ethyl]-1H-Indol-5-Yl]Methyl]Sulfonyl]Pyrrolidine Malate
• 1H-Indole-3-ethanamine, N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-
• 2-hydroxybutanedioic acid - N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine (1:1)
• Almogran
• Almotriptan Malate
• Almotriptan Maleate
• Almotriptanmaleate
• Butanedioic acid, hydroxy-, compd with 1-[[[3-[2-(dimethylamino)ethyl]-1h-indol-5-yl]methyl]sulfonyl]pyrrolidine
• Las 31416
• Las-31416 Malate
• N,N-Dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-indole-3-ethanamine
• N,N-dimethyl-2-{5-[(pyrrolidin-1-ylsulfonyl)methyl]-1H-indol-3-yl}ethanamine
• Pyrrolidine, 1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]-

Almotriptan

CAS: 154323-57-6

Almotriptan

Purity: ≥98%

Molecular weight: 335.46g/mol

Ref: 54-BUP06590

Almotriptan Malate

CAS: 154323-57-6, 181183-52-8

Formula: C₁₇H₂₅N₃O₂S·C₄H₆O₅

Purity: >98.0%(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 469.55

Ref: 3B-A3111

Almotriptan

CAS: 154323-57-6

Almotriptan (LAS 31416), a triptan and 5-HT1B/1D agonist, treats migraines by constricting cranial vessels and altering blood flow.

Formula: C₁₇H₂₅N₃O₂S

Purity: 99.85%

Color and Shape: Light Yellow Or White Power

Molecular weight: 335.46

Ref: TM-T21231

Almotriptan N-Di-methyl Dimer Malate

Controlled Product

CAS: 154323-57-6

Applications Almotriptan N-Di-methyl Dimer Malate is an impurity of Almotriptan (A575200), which is a serotonin 5HT1B /1D-receptor agonist used for the treatment of migraines.
References Fleishaker, J.C., et al.: Clin. Pharmacol. Ther., 67, 498 (2000), Kamali, F., et al.: Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs, 2, 197 (2000), Dodick, D.W., et al.: Expert Opin.Pharmacother., 4, 1157 (2003)

Formula: C₃₀H₄₁N₅O₂S•C₄H₆O₅

Color and Shape: Neat

Molecular weight: 535.74 + (134.09)

Ref: TR-A440015