CAS 154598-52-4
:Efavirenz
Description:
Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) primarily used in the treatment of HIV infection. It is characterized by its ability to inhibit the reverse transcriptase enzyme, which is crucial for the replication of the HIV virus. Chemically, efavirenz is a lipophilic compound, which contributes to its pharmacokinetic properties, including a long half-life and the ability to penetrate the central nervous system. The substance is typically administered orally and is often part of combination therapy to enhance efficacy and reduce the risk of resistance. Efavirenz is known for its side effects, which can include neuropsychiatric symptoms, rash, and potential effects on liver function. Its mechanism of action involves binding to the reverse transcriptase enzyme, leading to disruption of viral RNA conversion to DNA. The compound is classified under the World Health Organization's List of Essential Medicines, highlighting its importance in global health. As with any medication, monitoring for adverse effects and drug interactions is essential during treatment.
Formula:C14H9ClF3NO2
InChI:InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1
InChI key:InChIKey=XPOQHMRABVBWPR-ZDUSSCGKSA-N
SMILES:C(#CC1CC1)[C@@]2(C(F)(F)F)C=3C(NC(=O)O2)=CC=C(Cl)C3
Synonyms:- (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
- (4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-4-(2-Cyclopropylethynyl)-6-chloro-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-4-(Cyclopropylethynyl)-6-chloro-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
- (S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
- (S)-Efavirenz
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-
- 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (S)-
- Dmp 266
- Efavuirenz
- L 743726
- Stocrin
- See more synonyms
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Found 18 products.
Efavirenz
CAS:Formula:C14H9ClF3NO2Purity:>98.0%(HPLC)(N)Color and Shape:White to Almost white powder to crystalMolecular weight:315.68Efavirenz
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFormula:C14H9ClF3NO2Color and Shape:White Off-White Yellow Pink Crystalline PowderMolecular weight:315.67 g/mol(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one
CAS:Formula:C14H9ClF3NO2Purity:98%Color and Shape:SolidMolecular weight:315.6750Efavirenz
CAS:Formula:C14H9ClF3NO2Purity:≥ 98.0%Color and Shape:White to off-white crystalline powderMolecular weight:315.68Efavirenz
CAS:Efavirenz (DMP 266) is an HIV-1 inhibitor, affecting reverse transcriptase and various cytochrome P450 enzymes.Formula:C14H9ClF3NO2Purity:99.2% - 99.84%Color and Shape:White To Slightly Pink Crystalline PowderMolecular weight:315.67(S)-Efavirenz
CAS:<p>Applications A nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>Formula:C14H9ClF3NO2Color and Shape:NeatMolecular weight:315.68Efavirenz
CAS:Efavirenz is a non-nucleoside-based reverse transcriptase inhibitor (NNRTI) of the reverse transcriptase of HIV-1. It inhibits the viral enzyme reverse transcriptase by binding to its active site. In certain cell culture assays, efavirenz showed great efficiency when inhibiting wild-type HIV-1 replication with values of inhibition constant Ki between 2.97 to 17.60 mM in single mutation enzymes and 26.05 to 56.50 nM in double mutation. In the treatment of HIV, efavirenz has been studied in combination with emtricitabine and tenofovir disoproxil fumarate for ease of administration in some clinical studies. Recent in vitro cell studies indicated efavirenz is a potential treatment for pancreatic, prostate and triple-negative breast cancers due to its cytotoxicity against cancer cells, with an EC50 of 31.5 μM.Formula:C14H9ClF3NO2Purity:Min. 95%Color and Shape:PowderMolecular weight:315.68 g/molEfavirenz - Bio-X ™
CAS:<p>Efavirenz is a non-nucleoside-based reverse transcriptase inhibitor (NNRTI) of the reverse transcriptase of HIV-1. It inhibits the viral enzyme reverse transcriptase by binding to its active site. In certain cell culture assays, Efavirenz showed great efficiency when inhibiting wild-type HIV-1 replication. In the treatment of HIV, Efavirenz has been studied in combination with Emtricitabine and Tenofovir disoproxil fumarate for ease of administration in some clinical studies. Recent in vitro cell studies indicated Efavirenz is a potential treatment for pancreatic, prostate and triple-negative breast cancers due to its cytotoxicity against cancer cells.Efavirenz is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C14H9ClF3NO2Purity:Min. 95%Color and Shape:PowderMolecular weight:315.67 g/mol(4S)-6-CHLORO-4-(CYCLOPROPYLETHYNYL)-1,4-DIHYDRO-4-(TRIFLUOROMETHYL)-2H-3,1-BENZOXAZIN-2-ONE
CAS:Purity:98%Molecular weight:315.6799927rac Efavirenz-8-d1
CAS:Controlled ProductFormula:C14DH8ClF3NO2Color and Shape:NeatMolecular weight:316.681(S)-7,14-Dihydroxy Efavirenz
CAS:Controlled ProductFormula:C14H9ClF3NO4Color and Shape:NeatMolecular weight:347.674
