CAS 154652-83-2

TEZAMPANEL

Description:

Tezampanel is a chemical compound classified as a selective antagonist of the AMPA receptor, which is a subtype of glutamate receptors in the central nervous system. Its primary function is to inhibit excitatory neurotransmission, making it a subject of interest in the study of neurological disorders, particularly those involving excessive neuronal activity, such as epilepsy and neurodegenerative diseases. Tezampanel has been investigated for its potential therapeutic effects in managing pain and other conditions linked to glutamate dysregulation. The compound is characterized by its specific binding affinity to AMPA receptors, which distinguishes it from other glutamate receptor antagonists. In terms of its physical properties, Tezampanel is typically presented as a white to off-white solid, and its solubility and stability can vary depending on the formulation and conditions. As with many pharmacological agents, understanding its pharmacokinetics, metabolism, and potential side effects is crucial for its application in clinical settings.

Formula: C₁₃H₂₁N₅O₂

InChI: InChI=1/C13H21N5O2/c19-13(20)11-6-10-5-8(1-3-9(10)7-14-11)2-4-12-15-17-18-16-12/h8-11,14H,1-7H2,(H,19,20)(H,15,16,17,18)/t8-,9+,10-,11+/m1/s1

InChI key: InChIKey=ZXFRFPSZAKNPQQ-YTWAJWBKSA-N

SMILES: C(CC=1NN=NN1)[C@@H]2C[C@]3([C@@](CC2)(CN[C@H](C(O)=O)C3)[H])[H]

Synonyms:

• (3S,4aR,6R,8aR)-Decahydro-6-[2-(2H-tetrazol-5-yl)ethyl]-3-isoquinolinecarboxylic acid
• 3-Isoquinolinecarboxylic acid, decahydro-6-(2-(1H-tetrazol-5-yl)ethyl)-, (3S,4aR,6R,8aR)-
• 3-Isoquinolinecarboxylic acid, decahydro-6-(2-(1H-tetrazol-5-yl)ethyl)-, (3S-(3alpha,4aalpha,6beta,8aalpha))-
• 3-Isoquinolinecarboxylic acid, decahydro-6-[2-(1H-tetrazol-5-yl)ethyl]-, [3S-(3α,4aα,6β,8aα)]-
• 3-Isoquinolinecarboxylic acid, decahydro-6-[2-(2H-tetrazol-5-yl)ethyl]-, (3S,4aR,6R,8aR)-
• 6-(2-(1H-Tetrazol-5-yl)ethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid
• Decahydro-6-(2-(1H-tetrazol-5-yl)ethyl)-3-isoquinolinecarboxylic acid
• Ly 293558
• Ngx 424
• TED-isoquinoline-3-COOH
• Tezampanel (anhydrous)
• Unii-Ga36S2O9C2
• LY 293558; LY293558; LY-293558
• LY293558
• (3S,4aR,6R,8aR)-Decahydro-6-[2-(1H-tetrazol-5-yl)ethyl]-3-isoquinolinecarboxylic acid

Tezampanel

CAS: 154652-83-2

Formula: C₁₃H₂₁N₅O₂

Molecular weight: 279.34

Ref: 4Z-T-162001

Tezampanel

CAS: 154652-83-2

Tezampanel is an investigational drug classified as an AMPA receptor antagonist, which is derived from synthetic chemical processes. It acts as an antagonist by selectively inhibiting the binding of glutamate to AMPA receptors, a subtype of ionotropic glutamate receptors that mediate fast synaptic transmission in the central nervous system. By blocking these receptors, Tezampanel reduces excitatory neurotransmission, which can mitigate the excessive neuronal excitation associated with various neurological disorders.

Formula: C₁₃H₂₁N₅O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 279.34 g/mol

Ref: 3D-EGA65283