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CAS 155-10-2

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2-Chloro-5-fluoro-4-pyrimidinamine

Description:
2-Chloro-5-fluoro-4-pyrimidinamine is a heterocyclic organic compound characterized by a pyrimidine ring substituted with both chlorine and fluorine atoms, as well as an amino group. The presence of these substituents imparts unique chemical properties, making it a valuable compound in medicinal chemistry and agrochemicals. The chlorine atom typically enhances lipophilicity, while the fluorine atom can improve metabolic stability and bioactivity. The amino group contributes to the compound's basicity and potential for hydrogen bonding, which can influence its interactions with biological targets. This compound is often utilized in the synthesis of pharmaceuticals, particularly in the development of antiviral and anticancer agents. Its reactivity can be attributed to the electron-withdrawing effects of the halogen substituents, which can facilitate nucleophilic attacks in further chemical reactions. Overall, 2-Chloro-5-fluoro-4-pyrimidinamine serves as an important building block in various chemical syntheses and research applications.
Formula:C4H3ClFN3
InChI:InChI=1S/C4H3ClFN3/c5-4-8-1-2(6)3(7)9-4/h1H,(H2,7,8,9)
InChI key:InChIKey=SLQAJWTZUXJPNY-UHFFFAOYSA-N
SMILES:NC=1C(F)=CN=C(Cl)N1
Synonyms:
  • 2-Chloro-4-amino-5-fluoropyrimidine
  • 2-Chloro-5-Fluoropyrimidin-4-Amine
  • 2-Chloro-5-fluoro-4-aminopyrimidine
  • 2-Chloro-5-fluoro-4-pyrimidinamine
  • 2-Chloro-5-fluoro-pyrimidin-4-ylamine
  • 2-Chloro-5-fluoropyrimidin-4-ylamine
  • 4-Pyrimidinamine, 2-chloro-5-fluoro-
  • NSC 78716
  • Pyrimidine, 4-amino-2-chloro-5-fluoro-
  • 4-Amino-2-chloro-5-fluoropyrimidine
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