CAS 155-12-4

2-chloro-5-fluoropyrimidin-4-ol

Description:

2-Chloro-5-fluoropyrimidin-4-ol is a heterocyclic organic compound characterized by its pyrimidine ring structure, which contains both chlorine and fluorine substituents. The presence of the hydroxyl (-OH) group at the 4-position contributes to its reactivity and solubility in polar solvents. This compound typically exhibits moderate to high polarity due to the electronegative halogen atoms and the hydroxyl group, influencing its interactions in chemical reactions and biological systems. It is often utilized in pharmaceutical chemistry and as an intermediate in the synthesis of various bioactive compounds. The chlorine and fluorine substituents can enhance the compound's biological activity and lipophilicity, making it of interest in medicinal chemistry. Additionally, 2-chloro-5-fluoropyrimidin-4-ol may exhibit specific spectral characteristics in techniques such as NMR and IR spectroscopy, aiding in its identification and characterization. Safety data should be consulted, as halogenated compounds can pose health risks, and appropriate handling procedures should be followed in laboratory settings.

Formula: C₄H₂ClFN₂O

InChI: InChI=1/C4H2ClFN2O/c5-4-7-1-2(6)3(9)8-4/h1H,(H,7,8,9)

SMILES: c1c(c(nc(Cl)n1)O)F

Synonyms:

• 2-Chloro-5-Fluoropyrimidin-4-One
• 2-Chloro-5-fluoro-pyrimidin-4-ol
• 4(1H)-Pyrimidinone, 2-chloro-5-fluoro- (9CI)
• 2-chloro-5-fluoropyrimidin-4(3H)-one
• 2-Chloro-4-hydroxy-5-fluoropyrimidine

4(3H)​-​Pyrimidinone, 2-​chloro-​5-​fluoro-

CAS: 155-12-4

Formula: C₄H₂ClFN₂O

Purity: 95%

Color and Shape: Solid

Molecular weight: 148.5229

Ref: IN-DA001NJR

2-Chloro-5-fluoropyrimidin-4(3H)-one

CAS: 155-12-4

2-Chloro-5-fluoropyrimidin-4(3H)-one

Purity: 98%

Color and Shape: Solid

Molecular weight: 148.52g/mol

Ref: 54-PC51106

2-Chloro-4-hydroxy-5-fluoropyrimidine

CAS: 155-12-4

Ref: 7W-GN5769

Abemaciclib Impurity 36

CAS: 155-12-4

Formula: C₄H₂ClFN₂O

Molecular weight: 148.52

Ref: 4Z-A-253044

2-Chloro-5-fluoro-4-pyrimidinone

CAS: 155-12-4

Formula: C₄H₂ClFN₂O

Purity: >98.0%(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 148.52

Ref: 3B-C3381

2-Chloro-5-fluoropyrimidin-4-one

CAS: 155-12-4

Formula: C₄H₂ClFN₂O

Purity: 95%

Color and Shape: Solid

Molecular weight: 148.52

Ref: 10-F076465

2-Chloro-4-hydroxy-5-fluoropyrimidine

CAS: 155-12-4

2-Chloro-4-hydroxy-5-fluoropyrimidine is a nucleoside with antiviral and anticancer activity. It has shown to be an effective agent against HIV, herpes virus and human papilloma virus. 2-Chloro-4-hydroxy-5-fluoropyrimidine inhibits the synthesis of DNA by inhibiting the enzyme DNA polymerase, which catalyzes the formation of diphosphate from monophosphate. In addition, it inhibits protein synthesis by inhibiting ribonucleotide reductase, which catalyzes the conversion of ribonucleotides to deoxyribonucleotides.

Formula: C₄H₂ClFN₂O

Purity: Min. 95%

Molecular weight: 148.52 g/mol

Ref: 3D-NC11515