CAS 15500-66-0: Pancuronium bromide
Description:Pancuronium bromide is a synthetic neuromuscular blocking agent primarily used in anesthesia to facilitate intubation and provide muscle relaxation during surgical procedures. It belongs to the class of non-depolarizing neuromuscular blockers and works by competitively inhibiting the action of acetylcholine at the neuromuscular junction, leading to muscle paralysis. The substance is characterized by its long duration of action compared to other neuromuscular blockers, making it particularly useful in certain surgical contexts. Pancuronium bromide is typically administered intravenously and is known for its minimal cardiovascular effects, although it can cause tachycardia in some patients. Its chemical structure includes a steroid backbone, which contributes to its pharmacological properties. The compound is soluble in water and has a relatively high molecular weight. Due to its potent effects, careful dosing and monitoring are essential to avoid complications such as prolonged paralysis or respiratory insufficiency. As with all neuromuscular blockers, pancuronium bromide should be used in a controlled medical environment with appropriate supportive measures in place.
Formula:C35H60N2O4·2Br
InChI:InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1
InChI key:InChIKey=NPIJXCQZLFKBMV-YTGGZNJNSA-L
SMILES:[Br-].O=C(OC1CC2CCC3C(CCC4(C)C(OC(=O)C)C(CC34)[N+]5(C)CCCCC5)C2(C)CC1[N+]6(C)CCCCC6)C
- Synonyms:
- 1,1'-(3α,17β-Dihydroxy-5α-androstan-2β,16β-ylene)bis[1-methylpiperidinium] dibromide diacetate
- 1,1'-[(2Β,3Α,5Α,16Β,17Β)-3,17-Bis(Acetyloxy)Androstane-2,16-Diyl]Bis(1-Methyl)Piperidinium Dibromide
- 2β,16β-Dipiperidino-5α-androstane-3α,17β-diol diacetate dimethobromide
- 5α-Androstane-3α,17β-diol, 2β,16β-bis(1-methylpiperidinio)-, dibromide, diacetate
- Androstane, piperidinium deriv.
- Bromure De Pancuronium
- Bromurex
- Bromuro De Pancuronio
- Mioblock
- Na 97
- See more synonyms
- Nsc 293162
- Org NA 97
- Org-NE 35
- Pancuronium
- Pancuronium Bromide
- Pancuronium dibromide
- Pancuroniumbromid
- Pavulon
- Piperidinium, 1,1'-(3α,17β-dihydroxy-5α-androstan-2β,16β-ylene)bis[1-methyl-, dibromide, diacetate
- (2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(1-methylpiperidinium-1-yl)androstane dibromide
- (2beta,3alpha,8xi,9xi,14xi,16beta,17beta)-3,17-bis(acetyloxy)-2,16-bis(1-methylpiperidinium-1-yl)androstane dibromide
- Piperidinium, 1,1′-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1-methyl-, dibromide
- 2-beta,16-beta-bis(1-methylpiperidinio)androstane-3-alpha,17-beta-diol 3-alpha,17-beta-di(acetate) dibromide
