CAS 155026-49-6

Z-Val-Val-Nle-diazomethylketone

Description:

Z-Val-Val-Nle-diazomethylketone, identified by its CAS number 155026-49-6, is a synthetic compound primarily used in biochemical research, particularly in the study of protease inhibitors. This substance features a diazomethylketone functional group, which is known for its reactivity and ability to form covalent bonds with nucleophilic sites in proteins, making it a valuable tool in the investigation of enzyme mechanisms. The "Z" in its name indicates that it has a specific stereochemistry, which can influence its biological activity and interaction with target enzymes. The presence of valine and norleucine residues suggests that it may mimic peptide substrates, allowing for selective inhibition of proteolytic enzymes. As with many diazomethylketones, it should be handled with care due to potential hazards associated with its reactivity and toxicity. Overall, Z-Val-Val-Nle-diazomethylketone serves as an important compound in the field of medicinal chemistry and enzymology, contributing to the development of therapeutic agents targeting proteases.

Formula: C₂₅H₃₇N₅O₅

Z-Val-Val-Nle-diazomethylketone

CAS: 155026-49-6

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Formula: C₂₅H₃₇N₅O₅

Purity: Min. 95%

Molecular weight: 487.59 g/mol

Ref: 3D-FV111568

Z-Val-Val-Nle-diazomethylketone

CAS: 155026-49-6

Z-Val-Val-Nle-diazomethylketone is an inhibitor of cathepsin S (CATS). It significantly suppresses the upregulation of IFNg-induced MHCII molecules, specifically HLA-DR and Ii-p33/35, while increasing the protein level of Ii-p10. This compound can be utilized for research into skin disorders such as psoriasis, atopic dermatitis, and actinic keratosis.

Formula: C₂₅H₃₇N₅O₅

Color and Shape: Solid

Molecular weight: 487.59

Ref: TM-TP3771