CAS 155069-90-2

CALCITONIN (8-32) (SALMON I)

Description:

Calcitonin (8-32) (Salmon I) is a synthetic peptide derived from salmon calcitonin, which is a hormone involved in calcium homeostasis and bone metabolism. This specific form consists of 32 amino acids, with the first eight amino acids being crucial for its biological activity. It is known for its potent ability to inhibit osteoclast activity, thereby reducing bone resorption and lowering blood calcium levels. The peptide exhibits a high degree of stability and bioactivity, making it useful in clinical applications, particularly in the treatment of conditions like osteoporosis and Paget's disease. Calcitonin (8-32) is characterized by its solubility in water and its ability to form stable complexes with calcium ions. Its mechanism of action involves binding to specific calcitonin receptors, leading to various physiological effects. Additionally, it has a relatively short half-life in circulation, necessitating careful dosing in therapeutic contexts. Overall, this peptide is a significant pharmacological agent in managing disorders related to calcium metabolism and bone health.

Formula: C₁₁₉H₁₉₈N₃₆O₃₇

Synonyms:

• Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-Nh2
• H-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-Nh2
• Calcitonin (8-32), Salmon

Calcitonin (8-32) (salmon I)

CAS: 155069-90-2

Calcitonin (8-32) (salmon I) has been been proposed as an amylin receptor antagonist which is highly selective for amylin. sCT 8-32 reverses the inhibitory effect of amylin on glucose-induced insulin release and potentiates the insulin response to glucose in the rat perfused pancreas.

Formula: C₁₁₉H₁₉₈N₃₆O₃₇

Purity: > 97%

Color and Shape: White

Molecular weight: 2725.1

Ref: 01-4037182

8-32-Calcitonin (salmon reduced)

CAS: 155069-90-2

Formula: C₁₁₉H₁₉₈N₃₆O₃₇

Purity: 99.89%

Color and Shape: Solid

Molecular weight: 2725.0644

Ref: IN-DA001NLE

Calcitonin (8-32), salmon

CAS: 155069-90-2

Calcitonin (8-32), salmon: selective amylin receptor antagonist, regulates calcium/phosphorus, thyroid origin, 32-aa peptide.

Formula: C₁₁₉H₁₉₈N₃₆O₃₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 2725.06

Ref: TM-TP1677

Calcitonin (8-32) (salmon I) trifluoroacetate salt

CAS: 155069-90-2

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Formula: C₁₁₉H₁₉₈N₃₆O₃₇·C₂HF₃O₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 2,725.07 g/mol

Ref: 3D-FC109515