CAS 155213-67-5

Ritonavir

Description:

Ritonavir is an antiretroviral medication primarily used in the treatment of HIV/AIDS. It belongs to the class of protease inhibitors, which work by inhibiting the protease enzyme, crucial for the viral replication process. Ritonavir is characterized by its complex molecular structure, which includes a series of functional groups that contribute to its pharmacological activity. It is typically administered orally and is known for its ability to enhance the effectiveness of other antiretroviral drugs when used in combination therapy. Ritonavir is also notable for its role in pharmacokinetic boosting, where it increases the plasma concentration of other protease inhibitors, allowing for lower doses and reduced side effects. The substance is relatively stable under standard conditions but should be stored properly to maintain its efficacy. Common side effects may include gastrointestinal disturbances, fatigue, and metabolic changes. Due to its significant role in HIV treatment regimens, Ritonavir has been a critical component in managing the disease and improving patient outcomes.

Formula: C₄H₅NOS

InChI: InChI=1/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1

InChI key: InChIKey=NCDNCNXCDXHOMX-XGKFQTDJSA-N

SMILES: [C@H](CC1=CC=CC=C1)(C[C@@H]([C@H](CC2=CC=CC=C2)NC(OCC3=CN=CS3)=O)O)NC([C@@H](NC(N(CC=4N=C(C(C)C)SC4)C)=O)[C@H](C)C)=O

Synonyms:

• 1,3-Thiazol-5-Ylmethyl N-[(2S,3S,5R)-3-Hydroxy-5-[[(2S)-3-Methyl-2-[[Methyl-[(2-Propan-2-Yl-1,3-Thiazol-4-Yl)Methyl]Carbamoyl]Amino]Butanoyl]Amino]-1,6-Diphenyl-Hexan-2-Yl]Carbamate
• 2,4,7,12-Tetraazatridecan-13-oic acid, 10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-
• 2,4,7,12-Tetraazatridecan-13-oic acid, 10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, [5S-(5R*,8R*,10R*,11R*)]-
• 2,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-
• A 84538
• Abbott 84538
• Abt 538
• Empetus
• N-[(1S,3S,4S)-1-benzyl-3-hydroxy-5-phenyl-4-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}pentyl]-N~2~-(methyl{[2-(1-methylethyl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
• N-[(2S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)valinamide
• NSC 693184
• Norvir
• Novir
• Ritomune
• Ritovir
• Viriton
• thiazol-5-ylmethyl (2S,3S,5S)-3-hydroxy-5-((S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-1,6-diphenylhexan-2-ylcarbamate
• Liponavir Core
• RITONAVIR
• Ethinyl Estradiol, Powder
• 2,4,7,12-Tetraazatridecan-13-oic acid, 10-hydroxy-2-methyl-5-(1-methylethyl)-1-[2-(1-methylethyl)-4-thiazolyl]-3,6-dioxo-8,11-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (5S,8S,10S,11S)-(9CI)
• THIAZOL-5-YL-METHANOL
• CHEMBRDG-BB 4050354
• Norvi
• 1,3-THIAZOL-5-YLMETHANOL
• (3S,4S,6S,9S)-4-Hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid, 5-thiazolylmethyl Ester
• RARECHEM AL BD 1261
• 5-HYDROXYMETHYLTHIAZOLE

Ritonavir

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Purity: >98.0%(HPLC)(N)

Color and Shape: White to Almost white powder to crystaline

Molecular weight: 720.95

Ref: 3B-R0116

Ritonavir

CAS: 155213-67-5

Color and Shape: Neat

Ref: 61-FOR1034.00

RITONAVIR FOR PEAK IDENTIFICATION CRS

CAS: 155213-67-5

RITONAVIR FOR PEAK IDENTIFICATION CRS

Formula: C₃₇H₄₈N₆O₅S₂

Molecular weight: 720.9442

Ref: 41-Y0000706

RITONAVIR RS

CAS: 155213-67-5

RITONAVIR RS

Ref: 41-ICRS1421

Ritonavir

CAS: 155213-67-5

Ritonavir

Formula: C₃₇H₄₈N₆O₅S₂

Purity: 99.7%

Color and Shape: Off-White

Molecular weight: 720.31276

Ref: 47-1210

RITONAVIR CRS

CAS: 155213-67-5

RITONAVIR CRS

Formula: C₃₇H₄₈N₆O₅S₂

Color and Shape: White. Powder.

Molecular weight: 720.9442

Ref: 41-Y0000714

Ritonavir

CAS: 155213-67-5

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure

Formula: C₃₇H₄₈N₆O₅S₂

Color and Shape: White Tan Powder

Molecular weight: 720.31276

Ref: 45-1604803

Ritonavir Related Compounds Mixture

CAS: 155213-67-5

Diagnostic or lab reagents on a backing, prepared diagnostic or lab reagents whether or not on a backing, whether or not in the form of kits, nesoi

Color and Shape: White Light Yellow Powder

Ref: 45-1604814

Ritonavir

CAS: 155213-67-5

Ritonavir (ABT 538) inhibits HIV-1/2 proteases; serum proteins limit it but it enhances other HIV drugs by hindering P450 degradation.

Formula: C₃₇H₄₈N₆O₅S₂

Purity: 99.38% - 99.96%

Color and Shape: White Powder

Molecular weight: 720.94

Ref: TM-T1525

Ritonavir

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Color and Shape: White To Off-White Solid

Molecular weight: 720.95

Ref: 4Z-R-271

Ritonavir

CAS: 155213-67-5

Ritonavir

Purity: ≥98%

Molecular weight: 720.94g/mol

Ref: 54-BUP17784

Ritonavir

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 720.94

Ref: 7W-GP3714

Ritonavir

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 720.95

Ref: 10-F358080

Ritonavir

Controlled Product

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Color and Shape: Neat

Molecular weight: 720.94

Ref: 86-MM1034.00

Ritonavir

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Color and Shape: Neat

Molecular weight: 720.94

Ref: 04-C16815300

Ritonavir

CAS: 155213-67-5

Applications A selective HIV protease inhibitor. It is a COVID19-related research product.
References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006)

Formula: C₃₇H₄₈N₆O₅S₂

Color and Shape: Neat

Molecular weight: 720.94

Ref: TR-R535000

Ritonavir

CAS: 155213-67-5

Ritonavir has an anti-retroviral activity as it inhibits the protease enzymes specific of both HIV-1 and HIV-2. As an added functionality, ritonavir also inactivates significantly the cytochrome P4503A4 (CYP3A4) thus increasing the bioavailability or half-life of other co-administered drugs.

Formula: C₃₇H₄₈N₆O₅S₂

Purity: Min. 95%

Color and Shape: White Off-White Powder

Molecular weight: 720.95 g/mol

Ref: 3D-FR16561

Ritonavir - Bio-X ™

CAS: 155213-67-5

Ritonavir is a HIV protease inhibitor. It has an anti-retroviral activity as it inhibits the protease enzymes specific of both HIV-1 and HIV-2 and has been shown to be effective in controlling virus replication in humans and animals. Ritonavir works by preventing the HIV viral protease enzyme from cleaving the structural and replicative proteins produced by HIV genes such as gag and pol.

Formula: C₃₇H₄₈N₆O₅S₂

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 720.95 g/mol

Ref: 3D-BR164353

2,7,10,12-Tetraazatridecanoic acid, 4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-, 5-thiazolylmethyl ester, (3S,4S,6S,9S)-

CAS: 155213-67-5

Formula: C₃₇H₄₈N₆O₅S₂

Purity: ≥98%

Color and Shape: Solid

Molecular weight: 720.9442

Ref: IN-DA001NQ6