CAS 155270-99-8

Istradefylline

Description:

Istradefylline is a selective adenosine A2A receptor antagonist primarily used in the treatment of Parkinson's disease, particularly as an adjunct therapy to improve motor function in patients experiencing "off" episodes while on standard dopaminergic treatments. It is characterized by its ability to modulate neurotransmitter release, thereby influencing motor control and reducing the severity of symptoms associated with Parkinson's. The compound has a molecular formula that reflects its complex structure, which includes multiple functional groups that contribute to its pharmacological activity. Istradefylline is administered orally and has a specific pharmacokinetic profile, including absorption, distribution, metabolism, and excretion characteristics that are important for its therapeutic efficacy and safety. Common side effects may include dyskinesia, hallucinations, and gastrointestinal disturbances. Its development represents a significant advancement in the management of Parkinson's disease, offering an alternative mechanism of action compared to traditional dopaminergic therapies.

Formula: C₂₀H₂₄N₄O₄

InChI: InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+

InChI key: InChIKey=IQVRBWUUXZMOPW-PKNBQFBNSA-N

SMILES: CN1C2=C(N(CC)C(=O)N(CC)C2=O)N=C1/C=C/C3=CC(OC)=C(OC)C=C3

Synonyms:

• (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione
• (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methylxanthine
• 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3,4-dimethoxyphenyl)ethenyl)-7-methyl-, (E)-
• 1H-Purine-2,6-dione, 8-((1E)-2-(3,4-dimethoxyphenyl)ethenyl)-1,3-diethyl-3,7-dihydro-7-methyl-
• 1H-Purine-2,6-dione, 8-[2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-, (E)-
• 8-((1E)-2-(3,4-Dimethoxyphenyl)ethenyl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione
• 8-[(1E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione
• 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione
• 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6-dione
• Kw 6002
• Nourianz
• Nouriast
• Unii-2Gz0Lik7T4

Istradefylline

CAS: 155270-99-8

Formula: C₂₀H₂₄N₄O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 384.44

Ref: 3B-I1100

1H-Purine-2,6-dione, 8-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-

CAS: 155270-99-8

Formula: C₂₀H₂₄N₄O₄

Purity: 99%

Color and Shape: Solid

Molecular weight: 384.4290

Ref: IN-DA001NRQ

Istradefylline-13C-d3

CAS: 155270-99-8

Formula: C₁₉₁₃CH₂₁D₃N₄O₄

Color and Shape: Pale Yellow Solid

Molecular weight: 388.45

Ref: 4Z-I-064013

Istradefylline

CAS: 155270-99-8

Istradefylline

Purity: ≥98%

Molecular weight: 384.43g/mol

Ref: 54-BUP15556

Istradefylline

CAS: 155270-99-8

Formula: C₂₀H₂₄N₄O₄

Color and Shape: Pale Green Solid

Molecular weight: 384.44

Ref: 4Z-I-064011

Istradefylline

CAS: 155270-99-8

Istradefylline

Purity: 99%

Molecular weight: 384.43g/mol

Ref: 54-OR1025468

Istradefylline

CAS: 155270-99-8

Istradefylline (KW-6002)(Ki of 2.2 nM) is a selective adenosine A2A receptor (A2AR) antagonist, which is under development in Phase 3 trails.

Formula: C₂₀H₂₄N₄O₄

Purity: 98.18% - 99.95%

Color and Shape: Solid

Molecular weight: 384.43

Ref: TM-T6552

Istradefylline

CAS: 155270-99-8

Applications Istradefylline is a selective A(2A) antagonist used in the treatment of Parkinson’s disease.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Dungo, R. et al.: Drugs., 73, 875 (2013); Stoessel, A. et al.: J. Med. Chem., 56, 4580 (2013);

Formula: C₂₀H₂₄N₄O₄

Color and Shape: Neat

Molecular weight: 384.43

Ref: TR-I927000

Istradefylline

Controlled Product

CAS: 155270-99-8

Adenosine A2A receptor antagonist

Formula: C₂₀H₂₄N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 384.43 g/mol

Ref: 3D-FI32579

Istradefyline - Bio-X ™

CAS: 155270-99-8

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₀H₂₄N₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 384.43 g/mol

Ref: 3D-BI164592

8-[(E)-2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methyl-purine-2,6 -dione

CAS: 155270-99-8

Formula: C₂₀H₂₄N₄O₄

Purity: 99%

Color and Shape: Solid, Crystalline Powder or Powder

Molecular weight: 384.436

Ref: 10-F237499

Istradefylline-d3,13C

Controlled Product

CAS: 155270-99-8

Formula: CC₁₉D₃H₂₁N₄O₄

Color and Shape: Neat

Molecular weight: 388.44

Ref: TR-I927002