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CAS 1553-34-0

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Methixene hydrochloride

Description:
Methixene hydrochloride is an anticholinergic agent primarily used in the treatment of various movement disorders, particularly in the management of Parkinson's disease and drug-induced extrapyramidal symptoms. It functions by blocking the action of acetylcholine at muscarinic receptors, which helps to alleviate symptoms such as rigidity and tremors. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for formulation in various pharmaceutical preparations. Methixene hydrochloride has a relatively low toxicity profile, but like other anticholinergics, it may cause side effects such as dry mouth, blurred vision, constipation, and urinary retention. Its pharmacokinetics involve oral administration, with absorption occurring in the gastrointestinal tract. The drug's efficacy and safety profile make it a valuable option in the therapeutic arsenal for managing movement disorders, although it should be used with caution in patients with certain pre-existing conditions, such as glaucoma or prostate hypertrophy.
Formula:C20H23NS·ClH
InChI:InChI=1S/C20H23NS.ClH/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20;/h2-5,8-11,15,18H,6-7,12-14H2,1H3;1H
InChI key:InChIKey=RSXZRFHNNTTWCB-UHFFFAOYSA-N
SMILES:C(C1C=2C(SC=3C1=CC=CC3)=CC=CC2)C4CN(C)CCC4.Cl
Synonyms:
  • 1-Methyl-3-(thioxanthen-9-ylmethyl)-1-piperidine hydrochloride
  • 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine hydrochloride (1:1)
  • 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine hydrochloride hydrate
  • 9-(1-Methyl-3-piperidylmethyl)thioxanthene hydrochloride
  • 9H-Thioxanthene, piperidine deriv.
  • Methixene Hydrochloride
  • NSC 78194
  • Piperidine, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-, hydrochloride
  • Piperidine, 1-methyl-3-(9H-thioxanthen-9-ylmethyl)-, hydrochloride (1:1)
  • Piperidine, 1-methyl-3-(thioxanthen-9-ylmethyl)-, hydrochloride
  • Tremaril hydrochloride
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Found 4 products.