CAS 1553-60-2

Ibufenac

Description:

Ibufenac, with the CAS number 1553-60-2, is a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic and anti-inflammatory properties. It is primarily used for the treatment of pain and inflammation associated with various conditions, such as arthritis. The chemical structure of ibufenac includes a carboxylic acid group, which is characteristic of many NSAIDs, allowing it to inhibit cyclooxygenase (COX) enzymes and subsequently reduce the synthesis of prostaglandins, mediators of inflammation and pain. Ibufenac is typically administered orally and is known for its relatively rapid onset of action. Its pharmacokinetics involve absorption in the gastrointestinal tract, with metabolism occurring primarily in the liver. While it is effective in managing pain and inflammation, potential side effects may include gastrointestinal discomfort, renal impairment, and allergic reactions, similar to other NSAIDs. As with any medication, it is important for users to consult healthcare professionals for appropriate dosing and to discuss any potential interactions with other medications.

Formula: C₁₂H₁₆O₂

InChI: InChI=1/C12H16O2/c1-9(2)7-10-3-5-11(6-4-10)8-12(13)14/h3-6,9H,7-8H2,1-2H3,(H,13,14)/p-1

InChI key: InChIKey=CYWFCPPBTWOZSF-UHFFFAOYSA-N

SMILES: C(C(C)C)C1=CC=C(CC(O)=O)C=C1

Synonyms:

• (p-Isobutylphenyl)acetic acid
• 2-(4-Isobutylphenyl)acetic acid
• 2-[4-(2-Methylpropyl)phenyl]acetic acid
• 4-(2-Methylpropyl)phenylacetic acid
• 4-Isobutoxyphenylacetic acid
• 4-Isobutylphenylacetic acid
• Acetic acid, (p-isobutylphenyl)-
• Benzeneacetic acid, 4-(2-methylpropyl)-
• Dytransin
• Ibufenac
• Ibunac
• Isodilan
• Medirex
• NSC 99976
• Rd 11654
• [4-(2-Methylpropyl)Phenyl]Acetate
• [4-(2-Methylpropyl)Phenyl]Acetic Acid
• 4-(2-Methylpropyl)benzeneacetic acid
• kyselinap-isobutylfenyloctova
• (p-isobutylphenyl)-aceticaci
• p-isobutyl-alpha-toluicacid
• 4-(2-Methylpropyl)benzeneaceticAcid,Dytransin,Ibunac
• 4-(2-methylpropyl)benzeneaceticacid
• 4-(2-methylpropyl)-benzeneaceticaci
• (p-isobutylphenyl)aceticacid
• 2-(4-Isobutylphenyl)

2-(4-Isobutylphenyl)acetic acid

CAS: 1553-60-2

2-(4-Isobutylphenyl)acetic acid

Formula: C₁₂H₁₆O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 192.25424

Ref: 54-OR965605

Ibufenac

CAS: 1553-60-2

2-(4-Isobutylphenyl)acetic acid

Formula: C₁₂H₁₆O₂

Purity: 98%

Molecular weight: 192.25

Ref: IN-DG134279

Benzeneacetic acid, 4-(2-methylpropyl)-

CAS: 1553-60-2

Formula: C₁₂H₁₆O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 192.2542

Ref: IN-DA001NTA

Ibufenac

CAS: 1553-60-2

Formula: C₁₂H₁₆O₂

Color and Shape: Off-White

Molecular weight: 192.25

Ref: 86-MM1872.00

Ibufenac

CAS: 1553-60-2

Formula: C₁₂H₁₆O₂

Molecular weight: 192.26

Ref: 4Z-I-179001

Ibufenac

CAS: 1553-60-2

Ibuprofen analogue; COX1/2 inhibitor

Formula: C₁₂H₁₆O₂

Purity: Min. 95%

Ref: 3D-FI24526

4-Isobutylphenylacetic acid

CAS: 1553-60-2

Formula: C₁₂H₁₆O₂

Purity: 98%

Color and Shape: Solid, Crystalline Powder

Molecular weight: 192.258

Ref: 10-F092095

Ibufenac-13C6

Controlled Product

CAS: 1553-60-2

Applications Ibufenac-13C6 is an intermediate in synthesizing Ibuprofen-13C6 (I140003), a labelled Ibuprofen. It is a selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency.
References Busson, M., et al.: J. Int. Med Res., 14, 53 (1986); Meade, E.A., et al.: J. Biol. Chem., 268, 6610 (1993); Davies, N.M., et al.: Clin. Pharmacokinet., 34, 101 (1998)

Formula: C₆C₆H₁₆O₂

Color and Shape: Neat

Molecular weight: 198.21

Ref: TR-I809017