CymitQuimica logo

CAS 155415-08-0

:

Inogatran

Description:
Inogatran is a synthetic chemical compound classified as a direct thrombin inhibitor, primarily developed for its anticoagulant properties. It is characterized by its ability to selectively inhibit thrombin, an enzyme crucial in the coagulation cascade, thereby preventing the formation of blood clots. Inogatran is typically administered via injection and has been investigated for its potential use in various clinical settings, including the prevention and treatment of thromboembolic disorders. The compound exhibits a relatively short half-life, which may necessitate frequent dosing or continuous infusion in therapeutic applications. Its pharmacokinetic profile includes rapid absorption and distribution, with metabolism primarily occurring in the liver. Inogatran's safety and efficacy have been evaluated in clinical trials, highlighting its potential advantages over traditional anticoagulants, such as a lower risk of certain bleeding complications. However, as with any anticoagulant, careful monitoring is essential to balance the therapeutic effects with the risk of adverse events. Overall, Inogatran represents a significant advancement in anticoagulant therapy, although its clinical use may vary based on regulatory approvals and ongoing research.
Formula:C21H38N6O4
InChI:InChI=1S/C21H38N6O4/c22-21(23)25-11-6-10-24-19(30)17-9-4-5-12-27(17)20(31)16(26-14-18(28)29)13-15-7-2-1-3-8-15/h15-17,26H,1-14H2,(H,24,30)(H,28,29)(H4,22,23,25)/t16-,17+/m1/s1
InChI key:InChIKey=CDPROXZBMHOBTQ-SJORKVTESA-N
SMILES:C([C@@H](CC1CCCCC1)NCC(O)=O)(=O)N2[C@H](C(NCCCNC(=N)N)=O)CCCC2
Synonyms:
  • Glycine, N-[2-[2-[[[3-[(aminoiminomethyl)amino]propyl]amino]carbonyl]-1-piperidinyl]-1-(cyclohexylmethyl)-2-oxoethyl]-, [S-(R*,S*)]-
  • Inogatran
  • N-[(1R)-2-[(2S)-2-[[[3-[(Aminoiminomethyl)amino]propyl]amino]carbonyl]-1-piperidinyl]-1-(cyclohexylmethyl)-2-oxoethyl]glycine
  • N-[(2R)-1-{(2S)-2-[(3-carbamimidamidopropyl)carbamoyl]piperidin-1-yl}-3-cyclohexyl-1-oxopropan-2-yl]glycine
  • glycine, N-[(1R)-2-[(2S)-2-[[[3-[(aminoiminomethyl)amino]propyl]amino]carbonyl]-1-piperidinyl]-1-(cyclohexylmethyl)-2-oxoethyl]-
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 2 products.
  • Inogatran
    Biosynth
    + Info

    Inogatran

    CAS:
    <p>Inogatran is a potent and selective inhibitor of the enzyme, activated C5a anaphylatoxin chemokine (C5a-AC) that is involved in the inflammatory response to tissue injury. Inogatran has been shown to inhibit the binding of C5a-AC to its receptor on neutrophils, macrophages, and eosinophils. The anti-platelet activity of inogatran is due to its ability to inhibit C5a-AC mediated platelet activation and aggregation. Inogatran also inhibits the release of tumor necrosis factor alpha (TNFα) from macrophages and inhibition of TNFα release suppresses tumour growth in vivo. In addition, inogatran significantly reduces melanoma growth by inhibiting the expression of melanoma antigen (MART-1).</p>
    Formula:C21H38N6O4
    Purity:Min. 95%
    Molecular weight:438.6 g/mol

    Ref: 3D-FGA41508

    ne
    To inquire
  • Inogatran
    Targetmol
    + Info

    Inogatran

    CAS:
    <p>Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of venous and arterial thrombotic diseases.</p>
    Formula:C21H38N6O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:438.56

    Ref: TM-T11659