CAS 155683-50-4

kistamicin A

Description:

Kistamicin A is a natural product belonging to the class of aminoglycoside antibiotics, characterized by its ability to inhibit bacterial protein synthesis. It is derived from the fermentation of certain actinomycetes, specifically from the genus Micromonospora. Kistamicin A exhibits a broad spectrum of antibacterial activity, particularly against Gram-positive bacteria, making it a potential candidate for therapeutic applications in treating bacterial infections. The compound's structure features multiple amino and sugar moieties, which contribute to its biological activity and solubility properties. Kistamicin A is known for its low toxicity profile compared to other aminoglycosides, which is advantageous in clinical settings. Its mechanism of action involves binding to the bacterial ribosome, disrupting the translation process, and ultimately leading to cell death. Research into kistamicin A continues to explore its efficacy, resistance mechanisms, and potential modifications to enhance its pharmacological properties. As with many antibiotics, the emergence of resistance highlights the need for ongoing studies to optimize its use in medical applications.

Formula: C₆₁H₅₁ClN₈O₁₅

Synonyms:

• 24H-14,17:29,32-Dietheno-27,13-(iminomethano)-1,38:19,23:34,37-trimethenopyrrolo(3',4':12,13)(1,4)diazacyclohexadecino(6,5-d)(1,13,7,20)dioxadiazacycloheptacosine-24-carboxylic acid, 5-(((2R)-2-amino-3-(4-hydroxyphenyl)-1-oxopropyl)amino)-16-chloro-8-(3,5-dihydroxyphenyl)-2,4,5,6,7,8,9,10,10a,11,12,13,25,26,27,28-hexadecahydro-20,42-dihydroxy-6,9,11,26,46-pentaoxo-, (5R,8R,10aR,13R,24R,27S)-
• Kistamycin A
• Glycine, D-tyrosyl-D-tryptophyl-(2R)-2-(3,5-dihydroxyphenyl)glycylglycyl-(2R)-2-(3-chloro-4-hydroxyphenyl)glycyl-L-tyrosyl-2-(3,4-dihydroxyphenyl)-, cyclic (5→73)-ether, cyclic [4(2R)]-26,42,6O-(6-hydroxy-1,3,5-benzenetriyl) deriv., (2R)-
• Kistamicin A
• kistamicin A

Kistamicin A

CAS: 155683-50-4

Kistamicin A exhibits antiviral properties, with an ID50 of 3.6 μg/mL against influenza virus in MDCK cells and 44 μg/mL against herpes simplex virus. It also demonstrates activity against Gram-positive bacteria.

Formula: C₆₁H₅₁ClN₈O₁₅

Color and Shape: Solid

Molecular weight: 1171.56

Ref: TM-TN10286