CAS 15585-43-0

Rivanicline

Description:

Rivanicline, with the CAS number 15585-43-0, is a chemical compound that functions primarily as a selective agonist for nicotinic acetylcholine receptors. It is particularly noted for its potential applications in the treatment of cognitive disorders and as a smoking cessation aid. The compound exhibits a high affinity for specific nicotinic receptor subtypes, which contributes to its pharmacological effects, including modulation of neurotransmitter release and enhancement of cognitive function. Rivanicline's mechanism of action involves mimicking the effects of acetylcholine, leading to increased neuronal activity. In terms of physical properties, rivanicline is typically characterized by its solubility in organic solvents and moderate stability under standard conditions. Its development has been of interest in both neuroscience and pharmacology, with ongoing research aimed at understanding its full therapeutic potential and side effect profile. As with many compounds targeting the central nervous system, careful consideration of dosage and individual patient response is crucial in clinical applications.

Formula: C₁₀H₁₄N₂

InChI: InChI=1S/C10H14N2/c1-11-7-3-2-5-10-6-4-8-12-9-10/h2,4-6,8-9,11H,3,7H2,1H3/b5-2+

InChI key: InChIKey=JUOSGGQXEBBCJB-GORDUTHDSA-N

SMILES: C(=C/CCNC)\C=1C=CC=NC1

Synonyms:

• (3E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine
• (3E)-N-Methyl-4-(pyridin-3-yl)but-3-en-1-amine
• (E)-Metanicotine
• 3-Buten-1-amine, N-methyl-4-(3-pyridinyl)-, (3E)-
• 3-Buten-1-amine, N-methyl-4-(3-pyridinyl)-, (E)-
• But-3-en-1-amine, N-methyl-4-(pyridin-3-yl)-, (E)-
• Pyridine, 3-[4-(methylamino)-1-butenyl]-, (E)-
• Rivanicline [INN]
• Rjr 2403
• Unii-6H35Lf645A
• trans-Metanicotine

Metanicotine

CAS: 15585-43-0

Formula: C₁₀H₁₄N₂

Color and Shape: Liquid

Molecular weight: 162.2316

Ref: IN-DA001O9Q

Metanicotine

Controlled Product

CAS: 15585-43-0

Applications An alkaloid found in the leaves of Duboisia Hopwoodii, and a constitutent of tobacco smoke. Also used a potential drug for the treatment of senile dementia of the Alzheimer’s type and currently being investigated as a nicotinic agonist with CNS selectivity. Metanicotine may have clinical potential due to its high selectivity for CNS nicotinic acetylcholine receptor subtypes relative to peripheral ganglionic and muscle-type nicotinic acetylcholine receptors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Schmeltz, I., et al.: J. Sci. Food Agric., 15, 744 (1964), Griffin, W.J. and Luanratana, O.: Phytochemistry, 21, 499 (1982), Jacob III, P., et al.: J. Chromatogr., 619, 49 (1993), Lippiello, P.M., et al.: J. Pharm. Exp. Therap., 279, 1422 (1996)

Formula: C₁₀H₁₄N₂

Color and Shape: Neat

Molecular weight: 162.23

Ref: TR-M321250

Rivanicline

CAS: 15585-43-0

Rivanicline is a selective α4β2 nicotinic receptor agonist (Ki=26 nM), with >1,000x less affinity for α7 receptors.

Formula: C₁₀H₁₄N₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 162.23

Ref: TM-T12738L