Fmoc-Asp-ODmb, with the CAS number 155866-25-4, is a chemical compound commonly used in peptide synthesis. It is a derivative of aspartic acid, where the amino group is protected by a fluorenylmethyloxycarbonyl (Fmoc) group, and the carboxylic acid is esterified with a 4,4-dimethoxybenzyl (Dmb) group. This structure allows for selective deprotection during peptide synthesis, facilitating the stepwise assembly of peptides. The Fmoc group is particularly advantageous due to its stability under basic conditions and ease of removal under mildly acidic conditions. The presence of the Dmb group provides additional protection for the carboxylic acid, which can be selectively removed under specific conditions, allowing for the formation of peptide bonds. Fmoc-Asp-ODmb is typically utilized in solid-phase peptide synthesis (SPPS), where its protective groups play a crucial role in ensuring the fidelity and efficiency of the synthesis process. Overall, this compound is valuable in the field of medicinal chemistry and biochemistry for the development of peptide-based therapeutics.

Fmoc-Asp-ODmb

155866-25-4: Fmoc-Asp-ODmb, with the CAS number 155866-25-4, is a chemical compound commonly used in peptide synthesis. It is a derivative of aspartic acid, where the amino group is protected by a fluorenylmethyloxycarbonyl (Fmoc) group, and the carboxylic acid is esterified with a 4,4-dimethoxybenzyl (Dmb) group. This structure allows for selective deprotection during peptide synthesis, facilitating the stepwise assembly of peptides. The Fmoc group is particularly advantageous due to its stability under basic conditions and ease of removal under mildly acidic conditions. The presence of the Dmb group provides additional protection for the carboxylic acid, which can be selectively removed under specific conditions, allowing for the formation of peptide bonds. Fmoc-Asp-ODmb is typically utilized in solid-phase peptide synthesis (SPPS), where its protective groups play a crucial role in ensuring the fidelity and efficiency of the synthesis process. Overall, this compound is valuable in the field of medicinal chemistry and biochemistry for the development of peptide-based therapeutics.

The highly acid-labile Dmb ester can be cleaved, e.g., with 1%TFA/DCM.

<p>Albumin is a major protein in the blood, which can be conjugated with Fmoc-L-Asp-ODmb to form an albumin conjugate. This albumin conjugate has been shown to have a strong binding affinity for Alzheimer's disease related amyloid beta peptides and thus could serve as a vaccine for this disease. The albumin conjugate may also be used as a tracer for Alzheimer's disease or other amyloid diseases. Additionally, the conjugate may be used in antibody detection methods such as enzyme-linked immunosorbent assay.</p>

CAS 155866-25-4

Fmoc-Asp-ODmb

Fmoc-Asp-ODmb

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