CAS 155974-00-8: Ivabradine

Description: Ivabradine is a selective heart rate-lowering agent primarily used in the treatment of certain cardiovascular conditions, particularly chronic stable angina and heart failure. It functions by inhibiting the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, specifically HCN4, which reduces the heart rate without significantly affecting myocardial contractility or blood pressure. Ivabradine is characterized by its unique mechanism of action, distinguishing it from traditional beta-blockers. The substance is typically administered orally and is well-absorbed, with a bioavailability that can be influenced by food intake. Its pharmacokinetics involve extensive hepatic metabolism, primarily through cytochrome P450 enzymes, leading to various metabolites. Ivabradine's efficacy is often evaluated through clinical trials, demonstrating its ability to improve exercise tolerance and reduce the frequency of angina attacks. Common side effects may include bradycardia, visual disturbances, and potential interactions with other medications. Overall, Ivabradine represents a valuable therapeutic option for managing heart rate in specific patient populations.

Formula: C₂₇H₃₆N₂O₅

InChI: InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1

InChI key: InChIKey=ACRHBAYQBXXRTO-OAQYLSRUSA-N

SMILES: O=C1N(CCC2=CC(OC)=C(OC)C=C2C1)CCCN(C)CC3C4=CC(OC)=C(OC)C=C4C3

Synonyms:

• (S)-3-(3-(((3,4-Dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one
• 2H-3-Benzazepin-2-one, 3-(3-(((3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, (S)-
• 2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-
• 3-(3-((((7S)-3,4-Dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one
• 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one
• 7,8-Dimethoxy-3-(3-(((4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one
• Bicyclo[4.2.0]octane, 2H-3-benzazepin-2-one deriv.
• Coraxan
• S 16257
• S 16257-2
• Unii-3H48L0Lpzq

Ivabradine Hydrochloride

CAS: 148849-67-6 155974-00-8

• Formula: C₂₇H₃₆N₂O₅·HCl
• Purity: >98.0%(HPLC)(N)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 505.05

2H-3-Benzazepin-2-one, 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-

CAS: 155974-00-8

• Formula: C₂₇H₃₆N₂O₅
• Molecular weight: 468.5851

Ivabradine hydrochloride

CAS: 155974-00-8

• Formula: C₂₅H₃₃ClN₂O₅
• Molecular weight: 476.99

Ivabradine-d3

CAS: 155974-00-8

• Formula: C₂₇H₃₃D₃N₂O₅
• Molecular weight: 471.62

Ivabradine

CAS: 155974-00-8

Ivabradine: oral HCN blocker, lowers heart rate without affecting blood pressure, has anticonvulsant and anti-anginal …

• Formula: C₂₇H₃₆N₂O₅
• Color and Shape: Liquid
• Molecular weight: 468.59

3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methyl-amino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4 -one

CAS: 155974-00-8

Ivabradine is a drug that lowers heart rate by blocking the rapid, repetitive firing of …

• Formula: C₂₇H₃₆N₂O₅
• Purity: Min. 95%
• Molecular weight: 468.59 g/mol