CAS 156001-18-2

Embusartan

Description:

Embusartan, with the CAS number 156001-18-2, is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which work by blocking the action of angiotensin II, a hormone that constricts blood vessels and increases blood pressure. This mechanism helps to relax blood vessels, thereby lowering blood pressure and reducing the risk of cardiovascular events. Embusartan is characterized by its selective binding to the AT1 receptor subtype, which is responsible for most of the physiological effects of angiotensin II. The compound is typically administered orally and is known for its favorable pharmacokinetic profile, including good bioavailability and a relatively long half-life, allowing for once-daily dosing. Additionally, it may have beneficial effects on renal function and is often considered in patients with comorbid conditions such as diabetes. As with other medications in its class, potential side effects may include dizziness, fatigue, and, in rare cases, renal impairment or hyperkalemia.

Formula: C₂₅H₂₄FN₅O₃

InChI: InChI=1/C25H24FN5O3/c1-3-4-7-19-12-18(25(33)34-2)14-23(32)31(19)15-17-11-10-16(13-22(17)26)20-8-5-6-9-21(20)24-27-29-30-28-24/h5-6,8-14H,3-4,7,15H2,1-2H3,(H,27,28,29,30)

SMILES: CCCCc1cc(cc(=O)n1Cc1ccc(cc1F)c1ccccc1c1n[nH]nn1)C(=O)OC

Synonyms:

• Embusartan [INN]
• Bay 10-6734
• 6-n-Butyl-4-methoxycarbonyl-2-oxo-1-((2'-(1H-tetrazol-5-yl)-3-fluorobiphenyl-4-yl)methyl)-1,2-dihydropyridine
• Methyl 6-butyl-1-((3-fluoro-2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1,2-dihydro-2-oxo-4-pyridinecarboxylate
• Methyl 6-butyl-1-((3-fluoro-2'-(1H-tetrzol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1,2-dihydro-2-oxo-4-pyridinecarboxylate
• Methyl 6-butyl-1-(2-fluoro-4-(o-1H-tetrazol-5-ylphenyl)benzyl)-1,2-dihydro-2-oxoisonicotinate
• Unii-4My73645Xa
• 4-Pyridinecarboxylic acid, 6-butyl-1-((3-fluoro-2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1,2-dihydro-2-oxo-, methyl ester
• 4-Pyridinecarboxylic acid, 6-butyl-1-((3-fluoro-2'-(1H-tetrzol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1,2-dihydro-2-oxo-, methyl ester
• methyl 6-butyl-1-{[3-fluoro-2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-2-oxo-1,2-dihydropyridine-4-carboxylate

Embusartan

CAS: 156001-18-2

Embusartan (BAY 10-6734) is a potent, orally active angiotensin II receptor antagonist used as an antihypertensive agent.

Formula: C₂₅H₂₄FN₅O₃

Color and Shape: Solid

Molecular weight: 461.49

Ref: TM-T31619