CAS 156161-89-6

B Q-788

Description:

B Q-788, identified by its CAS number 156161-89-6, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is characterized as a selective antagonist of certain receptors, which may contribute to its pharmacological effects. The compound is typically studied for its role in modulating biological pathways, potentially influencing conditions related to cardiovascular health and other physiological processes. Its molecular structure includes specific functional groups that enhance its binding affinity and selectivity for target receptors. Additionally, B Q-788's solubility, stability, and bioavailability are important factors that influence its efficacy and safety profile in research settings. As with many compounds in this category, ongoing studies aim to elucidate its mechanism of action, therapeutic potential, and any associated side effects, contributing to a better understanding of its role in drug development and clinical applications.

Formula: C₃₄H₅₀N₅O₇·Na

InChI: InChI=1/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q;+1/p-1/t21-,22+,25-,26-,27+;/m1./s1

InChI key: InChIKey=IASLQTYUGYPLFB-FUKQNADPSA-N

SMILES: C([C@@H](NC([C@@H](NC(=O)N1[C@@H](C)CCC[C@H]1C)CC(C)(C)C)=O)C(N[C@H](CCCC)C(O)=O)=O)C=2C=3C(N(C(OC)=O)C2)=CC=CC3.[Na]

Synonyms:

• <span class="text-smallcaps">D</smallcap>-Norleucine, N-[(cis-2,6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl-, monosodium salt
• <span class="text-smallcaps">D</smallcap>-Norleucine, N-[N-[N-[(2,6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl]-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl]-, monosodium salt, cis-
• <span class="text-smallcaps">D</smallcap>-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl-, monosodium salt
• <span class="text-smallcaps">D</smallcap>-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-<smallcap>L</smallcap>-leucyl-1-(methoxycarbonyl)-<smallcap>D</span>-tryptophyl-, sodium salt (1:1)
• BQ-788, Sodium Salt
• Bq 788
• sodium (2R)-2-{[(2S)-2-({[(2R,6S)-2,6-dimethylpiperidin-1-yl]carbonyl}amino)-4,4-dimethylpentanoyl][1-(methoxycarbonyl)-D-tryptophyl]amino}hexanoate
• sodium N-{[(2R,6S)-2,6-dimethylpiperidin-1-yl]carbonyl}-4-methyl-L-leucyl-N-[(1R)-1-carboxylatopentyl]-1-(methoxycarbonyl)-D-tryptophanamide
• D-Norleucine, N-[(cis-2,6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-, monosodium salt
• D-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-, sodium salt (1:1)
• D-Norleucine, N-[N-[N-[(2,6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-, monosodium salt, cis-
• D-Norleucine, N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-, monosodium salt
• sodium,(2R)-2-[[(2R)-2-amino-3-(1-methoxycarbonylindol-3-yl)propanoyl]-[(2S)-2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4,4-dimethylpentanoyl]amino]hexanoate
• BQ-788 SYNTHETIC >97% ETB ENDOTHELIN REC EPT
• N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-
• 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle
• N-cis-2,6-dimethylpiperidinocarbonyl-L-γMeLeu-D-Trp(COOMe)-D-Nle-ONa
• BQ788 SODIUM SALT; BQ 788 SODIUM SALT
• DMpc-gaMMa-MeLeu-D-Trp(1-CO2CH3)-D-Nle.Na (DMpc : cis-2,6-DiMethylpiperidinocarbonyl)
• N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucinesodiumsalt
• N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt, 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle
• BQ789 Sodium Salt
• N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt
• 1-ELAIDYLPHOSPHOCHOLINE, >97%
• BQ-788 SODIUM

BQ-788

CAS: 156161-89-6

Bachem ID: 4058874.

Formula: C₃₄H₅₀N₅NaO₇

Purity: 96.2%

Molecular weight: 663.79

Ref: 01-4058874

BQ-788 Sodium

CAS: 156161-89-6

Formula: C₃₄H₅₀N₅NaO₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 663.7799

Ref: IN-DA001OKH

Sodium (R)-2-((R)-2-((S)-2-((2R,6S)-2,6-dimethylpiperidine-1-carboxamido)-4,4-dimethylpentanamido)-3-(1-(methoxycarbonyl)-1H-indol-3-yl)propanamido)hexanoate

CAS: 156161-89-6

Sodium (R)-2-((R)-2-((S)-2-((2R,6S)-2,6-dimethylpiperidine-1-carboxamido)-4,4-dimethylpentanamido)-3-(1-(methoxycarbonyl)-1H-indol-3-yl)propanamido)hexanoate

Purity: 98%

Molecular weight: 663.79g/mol

Ref: 54-OR1074812

BQ-788 sodium salt

CAS: 156161-89-6

BQ-788 sodium salt is a potent and selective antagonist of ETB receptor(ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells).

Formula: C₃₄H₅₁N₅NaO₇

Color and Shape: Solid

Molecular weight: 664.8

Ref: TM-T10595L

BQ-788

CAS: 156161-89-6

Formula: C₃₄H₅₀N₅NaO₇

Molecular weight: 663.78

Ref: 7W-GK9247

BQ 788

CAS: 156161-89-6

Applications BQ 788 is an endothelin type B (ETB) receptor antagonist and is a potential antidote for the cardiovascular toxicity with hypotension and bradycardia.
References Arici, M.A.A., et. al.: Hum. Exp. Toxicol., 32, 316 (2013)

Formula: C₃₄H₅₀N₅O₇·Na

Color and Shape: Neat

Molecular weight: 663.78

Ref: TR-B676670

BQ 788-d2

Controlled Product

CAS: 156161-89-6

Formula: C₃₄D₂H₄₈N₅NaO₇

Color and Shape: Neat

Molecular weight: 665.792

Ref: TR-B676672