CAS 156223-05-1

DMXB-A

Description:

DMXB-A, with the CAS number 156223-05-1, is a synthetic compound that acts as a selective agonist for the alpha-7 nicotinic acetylcholine receptor (nAChR). This receptor is primarily found in the central nervous system and is implicated in various cognitive functions, including learning and memory. DMXB-A has been studied for its potential therapeutic effects in conditions such as schizophrenia and Alzheimer's disease, where modulation of cholinergic signaling may offer benefits. The compound is characterized by its ability to enhance cognitive performance and has shown promise in preclinical studies. Its chemical structure features a unique arrangement that allows for selective interaction with the alpha-7 nAChR, distinguishing it from other nicotinic agonists. Additionally, DMXB-A is noted for its favorable pharmacokinetic properties, which may contribute to its efficacy and safety profile in potential therapeutic applications. As research continues, DMXB-A may provide insights into the treatment of cognitive deficits associated with various neuropsychiatric disorders.

Formula: C₁₉H₂₀N₂O₂·2ClH

InChI: InChI=1S/C19H20N2O2.2ClH/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16;;/h3,6-9,11-13H,4-5,10H2,1-2H3;2*1H/b15-11+;;

InChI key: InChIKey=BXKYFUGAAFLYJL-BXGYHSFXSA-N

SMILES: C(=C\1/C(=NCCC1)C=2C=CC=NC2)\C3=C(OC)C=C(OC)C=C3.Cl

Synonyms:

• (3E)-3-[(2,4-dimethoxyphenyl)methylidene]-3,4,5,6-tetrahydro-2,3'-bipyridine dihydrochloride
• 2,3′-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, dihydrochloride, (3E)-
• 2,3′-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, dihydrochloride, (E)-
• 2,3′-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, hydrochloride (1:2), (3E)-
• 3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride
• DMBX-anabaseine
• Dmxb-A
• Gts 21
• 3-(2,4)-DiMethoxybenzylidineanabaseine
• GTS-21 (DMXB-A)
• GTS 21 DIHYDROCHLORIDE;DMXB-A;DMBX-ANABASEINE
• GTS 21 2hydrochloride
• GTS-21 (hydrochloride)
• GTS21;GTS 21;GTS-21
• GTS 21 2HCl(DMXBA)
• (3E)-3-[(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine dihydrochloride
• GTS-21HCl
• 3-(2,4-DiMethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl Dihydrochloride
• GTS 21 2HCl
• 3-(2,4-dimethoxybenzylidene)anabaseine
• GTS 21 dihydrochloride
• 3-(2,4-Dimethoxybenzylidene)-anabaseine dihydrochloride
• DMXB
• 3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl

GTS-21 dihydrochloride

CAS: 156223-05-1

GTS-21 dihydrochloride (DMBX-anabaseine) is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.

Formula: C₁₉H₂₀N₂O₂·2HCl

Purity: 98.54% - >99.99%

Color and Shape: Solid

Molecular weight: 381.3

Ref: TM-T2663

2,3'-Bipyridine, 3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-, hydrochloride (1:2), (3E)-

CAS: 156223-05-1

Formula: C₁₉H₂₂N₂O₂

Purity: %

Color and Shape: Solid

Molecular weight: 310.3902

Ref: IN-DA001OLQ

(E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-Tetrahydro-2,3'-Bipyridine Dihydrochloride

CAS: 156223-05-1

(E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-Tetrahydro-2,3'-Bipyridine Dihydrochloride

Purity: 98%

Molecular weight: 381.3g/mol

Ref: 54-OR1024341

GTS-21 dihydrochloride

CAS: 156223-05-1

GTS-21 dihydrochloride

Purity: ≥98%

Molecular weight: 381.3g/mol

Ref: 54-BUP13376

3-(2,4-Dimethoxybenzyl)-3,4,5,6-tetrahydro-2,3′-bipyridine

CAS: 156223-05-1

Formula: C₁₉H₂₂N₂O₂

Purity: 98+%

Molecular weight: 310.397

Ref: 10-F229924

GTS 21 Dihydrochloride

CAS: 156223-05-1

GTS-21 is a potent, selective and orally active amide that has been shown to modulate α7 nicotinic acetylcholine receptors in animal models. It also increases the levels of tyrosine kinase, which are expressed in cardiac tissue. GTS-21 has been shown to increase blood pressure and reduce the incidence of ventricular fibrillation in animals. This drug may be useful for treating ischemia/reperfusion injury, as it can inhibit fibroblast proliferation and transients. GTS-21 also potentiates acetylcholine by acting on acetylcholine receptors found on the heart muscle cells. This drug may have a role in treating patients with heart failure.

Formula: C₁₉H₂₀N₂O₂·2HCl

Purity: Min. 95%

Molecular weight: 308.37 g/mol

Ref: 3D-GGA22305