CAS 156223-06-2

Glycine, N-(N-(N-(N-(N-(N2-(9-hydroxy-1-oxo-10,12-octadecadienyl)-D-gl utaminyl)-L-threonyl)-beta-alanyl)-D-tryptophyl)-D-seryl)-, omicron-la ctone

Description:

The chemical substance known as Glycine, N-(N-(N-(N-(N-(N2-(9-hydroxy-1-oxo-10,12-octadecadienyl)-D-glutaminyl)-L-threonyl)-beta-alanyl)-D-tryptophyl)-D-seryl)-, omicron-lactone, with CAS number 156223-06-2, is a complex peptide derivative. It features a glycine backbone modified with multiple amino acid residues, including D-glutamine, L-threonine, beta-alanine, D-tryptophan, and D-serine, which contribute to its structural and functional properties. The presence of a long-chain fatty acid moiety (9-hydroxy-1-oxo-10,12-octadecadienyl) suggests potential amphiphilic characteristics, which may influence its solubility and interaction with biological membranes. The lactone formation indicates a cyclic structure that can affect the compound's stability and reactivity. Such compounds are often studied for their biological activities, including potential roles in signaling pathways or as therapeutic agents. Overall, this substance exemplifies the complexity of peptide chemistry and the potential for diverse biological applications.

Formula: C₄₆H₆₈N₈O₁₁

InChI: InChI=1/C46H68N8O11/c1-3-4-5-6-7-9-12-17-32(56)18-13-10-8-11-14-21-39(58)51-35(22-23-38(47)57)44(62)54-42-30(2)65-41(60)28-50-43(61)37(29-55)53-45(63)36(52-40(59)24-25-48-46(42)64)26-31-27-49-34-20-16-15-19-33(31)34/h7,9,12,15-17,19-20,27,30,32,35-37,42,49,55-56H,3-6,8,10-11,13-14,18,21-26,28-29H2,1-2H3,(H2,47,57)(H,48,64)(H,50,61)(H,51,58)(H,52,59)(H,53,63)(H,54,62)/b9-7+,17-12+

Synonyms:

• aselacin A
• N~1~-[6-(hydroxymethyl)-9-(1H-indol-3-ylmethyl)-17-methyl-2,5,8,11,15-pentaoxo-1-oxa-4,7,10,14-tetraazacycloheptadecan-16-yl]-N~2~-[(10E,12E)-9-hydroxyoctadeca-10,12-dienoyl]glutamamide
• Glycine, N-(N-(N-(N-(N-(N2-(9-hydroxy-1-oxo-10,12-octadecadienyl)-D-gl utaminyl)-L-threonyl)-beta-alanyl)-D-tryptophyl)-D-seryl)-, omicron-la ctone
• Glycine, N2-(9-hydroxy-1-oxo-10,12-octadecadien-1-yl)-D-glutaminyl-L-threonyl-β-alanyl-D-tryptophyl-D-seryl-, (6→2)-lactone

Aselacin A

CAS: 156223-06-2

Aselacin A targets the endothelin-1 receptor (ET-1 Receptor) and inhibits the binding of ET-1 to both ETA and ETB receptors. It effectively impedes the binding of ET-1 to bovine atrial membranes and porcine brain membranes, with IC50 values of 22 μg/mL and 20 μg/mL, respectively. Aselacin A is applicable for cardiovascular disease research.

Formula: C₄₆H₆₈N₈O₁₁

Color and Shape: Solid

Molecular weight: 909.079

Ref: TM-TN9071