CAS 156250-43-0

manumycin E

Description:

Manumycin E is a natural product belonging to the class of polyketides, specifically a type of antibiotic derived from the bacterium *Streptomyces*. It is characterized by its complex molecular structure, which includes multiple rings and functional groups that contribute to its biological activity. Manumycin E exhibits potent antibacterial and antifungal properties, making it of interest in pharmaceutical research. Its mechanism of action is primarily linked to the inhibition of specific enzymes involved in bacterial cell wall synthesis and other vital cellular processes. Additionally, manumycin E has shown potential in anticancer research due to its ability to induce apoptosis in certain cancer cell lines. The compound is typically studied in the context of its biosynthesis, structure-activity relationships, and potential therapeutic applications. As with many natural products, the extraction and purification processes can be challenging, and ongoing research aims to explore synthetic routes to enhance yield and efficacy. Overall, manumycin E represents a significant area of interest in the development of new antimicrobial and anticancer agents.

Formula: C₃₀H₃₄N₂O₇

InChI: InChI=1/C30H34N2O7/c1-20(2)13-9-5-3-4-6-10-14-24(35)31-21-19-30(38,29-28(39-29)27(21)37)18-12-8-7-11-15-25(36)32-26-22(33)16-17-23(26)34/h3-8,10-12,14-15,18-20,28-29,33,38H,9,13,16-17H2,1-2H3,(H,31,35)(H,32,36)/b5-3+,6-4+,8-7+,14-10+,15-11+,18-12+

Synonyms:

• 2,4,6-Undecatrienamide, N-(5-hydroxy-5-(7-((2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino)-7-oxo-1,3,5-heptatrienyl)-2-oxo-7-oxabicyclo(4.1.0)hept-3-en-3-yl)-10-methyl-
• manumycin E
• (2E,4E,6E)-N-(5-hydroxy-5-{(1E,3E,5E)-7-[(2-hydroxy-5-oxocyclopent-1-en-1-yl)amino]-7-oxohepta-1,3,5-trien-1-yl}-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)-10-methylundeca-2,4,6-trienamide
• Manumycin E
• 2,4,6-Undecatrienamide, N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5-heptatrienyl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-10-methyl-, (2E,4E,6E)-

Manumycin E

CAS: 156250-43-0

Manumycin E exhibits activity against Gram-positive bacteria and Escherichia coli, but has limited effect on other Gram-negative bacteria and none on fungi. It inhibits RAS farnesyltransferase and demonstrates modest cytotoxic activity against the human colorectal cancer cell line [HCT-116].

Formula: C₃₀H₃₄N₂O₇

Color and Shape: Solid

Molecular weight: 534.6

Ref: TM-TN10602