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CAS 15639-50-6

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Safingol

Description:
Safingol, with the CAS number 15639-50-6, is a synthetic sphingolipid analog that has garnered interest in biomedical research, particularly in the context of cancer therapy and neuroprotection. It is characterized by its ability to inhibit sphingosine kinase, an enzyme involved in the metabolism of sphingolipids, which plays a crucial role in cell signaling and apoptosis. Safingol is typically presented as a white to off-white solid and is soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), but has limited solubility in water. Its mechanism of action involves the modulation of ceramide and sphingosine levels, influencing cell growth and survival pathways. Due to its properties, Safingol has been studied for its potential therapeutic applications in various malignancies and neurodegenerative diseases. However, further research is necessary to fully elucidate its pharmacological effects and therapeutic efficacy in clinical settings.
Formula:C18H39NO2
InChI:InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18-/m0/s1
InChI key:InChIKey=OTKJDMGTUTTYMP-ROUUACIJSA-N
SMILES:C(CCCCCCCCCCCCCC)[C@@H]([C@H](CO)N)O
Synonyms:
  • (-)-threo-Dihydrosphingosine
  • (2S,3S)-2-Amino-1,3-octadecanediol
  • (2S,3S)-2-aminooctadecane-1,3-diol
  • 1,3-Octadecanediol, 2-amino-, (2S,3S)-
  • 1,3-Octadecanediol, 2-amino-, <span class="text-smallcaps">L</span>-threo-
  • 1,3-Octadecanediol, 2-amino-, [S-(R*,R*)]-
  • <span class="text-smallcaps">L</span>-(-)-threo-Sphinganine
  • <span class="text-smallcaps">L</span>-Threo-Dihydrosphingosine
  • <span class="text-smallcaps">L</span>-threo-2-Amino-1,3-octadecanediol
  • <span class="text-smallcaps">L</span>-threo-Safingol
  • See more synonyms
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