CAS 1564265-95-7

2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)-

Description:

2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)- is a complex organic compound characterized by its bicyclic structure, which includes a nitrogen atom in the ring system. The presence of a carbonitrile group indicates a functional group that contains a cyano (-C≡N) moiety, contributing to the compound's reactivity and potential applications in medicinal chemistry. The compound also features an amino acid derivative, suggesting potential biological activity, possibly as a pharmaceutical agent. The tricyclic structure implies a rigid conformation, which may influence its interaction with biological targets. The stereochemistry indicated by the (1R,3R,5R) and (2R) designations suggests specific spatial arrangements of atoms that can significantly affect the compound's properties, including its solubility, binding affinity, and overall biological activity. Overall, this compound's unique structural features make it of interest in the fields of organic synthesis and drug development.

Formula: C₁₈H₂₅N₃O₂

Synonyms:

• 2-Azabicyclo[3.1.0]hexane-3-carbonitrile, 2-[(2R)-2-aMino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-, (1R,3R,5R)-
• (R,R,R,R)-Saxagliptin
• (2’R,2R,cis)-Saxagliptin
• (R)-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinenitrile
• Saxagliptin Impurity 2(R,R,R,R-Isomer)
• Saxagliptin Enantiomer
• Saxagliptin (R,R,R,R)-Isomer

ent-Saxagliptin

CAS: 1564265-95-7

Formula: C₁₈H₂₅N₃O₂

Molecular weight: 315.42

Ref: 4Z-S-3240

(2’R,2R,cis)-Saxagliptin

Controlled Product

CAS: 1564265-95-7

Applications (2’R,2R,cis)-Saxagliptin is an impurity of Saxagliptin (S143500); a potent and selective reversible inhibitor of dipeptidyl peptidase-4 (DPP-IV) developed for the treatment of type 2 diabetes.
References Dong, J., et al.: Bioorg. Med. Chem., 22, 1383 (2014); Feng, J., et al.: J. Med. Chem., 50, 2297 (2007); Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2008); Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2008)

Formula: C₁₈H₂₅N₃O₂

Color and Shape: Neat

Molecular weight: 315.41

Ref: TR-S143475

(2R,2R,Cis)-saxagliptin

CAS: 1564265-95-7

(2R,2R,Cis)-saxagliptin is an analytical research and development (R&D) drug development API impurity HPLC standard that is a metabolite of saxagliptin. Saxagliptin is a drug product that has been approved for the treatment of type 2 diabetes. It has been shown to inhibit the activity of dipeptidyl peptidase-4 (DPP-4) in vitro and in vivo. Saxagliptin is a competitive inhibitor of DPP-4, which prevents it from breaking down incretin hormones such as glucagon-like peptide 1 (GLP-1). This results in increased levels of GLP-1, which improves blood glucose control. The purity level for this API impurity HPLC standard is high. Impurities are less than 0.5% and have been tested at various concentrations to ensure quality standards are met.

Formula: C₁₈H₂₅N₃O₂

Purity: Min. 95%

Molecular weight: 315.40 g/mol

Ref: 3D-PMC26595

Saxagliptin Impurity 56

CAS: 1564265-95-7

Formula: C₁₈H₂₅N₃O₂

Molecular weight: 315.42

Ref: ST-EA-CP-S19071