CAS 156543-00-9

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-carboxy(polyethylene glycol)

Description:

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-carboxy(polyethylene glycol), commonly referred to as DSPE-PEG, is a phospholipid derivative that features a hydrophobic tail composed of two stearic acid chains and a hydrophilic head group containing polyethylene glycol (PEG). This amphiphilic nature allows it to form stable lipid bilayers and micelles, making it particularly useful in drug delivery systems and nanomedicine. The PEG component enhances solubility in aqueous environments and provides a steric barrier that can reduce protein adsorption and improve circulation time in biological systems. DSPE-PEG is often utilized in the formulation of liposomes and nanoparticles for targeted drug delivery, as it can facilitate the incorporation of therapeutic agents and improve their bioavailability. Additionally, the carboxylic acid group in the structure allows for further functionalization, enabling conjugation with various biomolecules for specific targeting applications. Overall, DSPE-PEG is a versatile compound widely used in pharmaceutical and biomedical research.

Formula: (C₂H₄O)nC₄₃H₈₄NO₁₀P

Synonyms:

• Poly(oxy-1,2-ethanediyl), α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-
• Poly(oxy-1,2-ethanediyl), α-[6-hydroxy-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-, P-oxide, (R)-
• 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-carboxy(polyethylene glycol)
• MPEG-DSPE
• Poly(oxy-1,2-ethanediyl), α-[6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-methoxy-, (R)-

DSPE-mPEG-2000

CAS: 156543-00-9

DSPE-mPEG-2000, a PEG-based phospholipid, facilitates the synthesis of liposomes for cancer agent delivery [1] [2].

Formula: C₄₅H₈₈NO₁₁P

Color and Shape: Solid

Molecular weight: 849.6095

Ref: TM-T74228