CAS 15662-33-6: Ryanodine

Description: Ryanodine is a naturally occurring alkaloid derived from the plant *Ryania speciosa*, primarily known for its role as a potent modulator of calcium release in muscle cells. It specifically targets ryanodine receptors (RyRs), which are crucial for calcium ion release from the sarcoplasmic reticulum, thereby influencing muscle contraction and relaxation processes. The compound exhibits a complex structure characterized by a bicyclic core and several functional groups, contributing to its biological activity. Ryanodine is often utilized in pharmacological research to study muscle physiology and has implications in understanding various muscle disorders. Additionally, it has been investigated for its potential effects on cardiac and smooth muscle tissues. Due to its specific action on calcium channels, ryanodine is also of interest in the development of therapeutic agents for conditions related to calcium dysregulation. However, its use is limited by its toxicity and the need for careful dosing in experimental settings. Overall, ryanodine serves as a valuable tool in both basic and applied biological research.

Formula: C₂₅H₃₅NO₉

InChI: InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19-,20-,21-,22+,23+,24+,25+/m0/s1

InChI key: InChIKey=JJSYXNQGLHBRRK-YSOSZROBSA-N

SMILES: O=C(OC1C(O)(C(C)C)C2(C)C3(O)OC45C(O)C(C)CCC4(O)C(C)(C3)C1(O)C52O)C6=CC=CN6

Synonyms:

• Ryania
• Ryanodine
• Ryania [ISO]
• Bonide ryatox
• Ground ryania specisa(vahl) stemwood (alkoloid ryanodine)
• Nsc 114572
• Ryanexel
• Ryania powder
• Ryania speciosa
• Ryanicide
• 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo(1,2)pentaleno(1,6-bc)furan-8-yl ester
• 6-(1alpha,5Abeta,8abeta,9-pentahydroxy-7beta-isopropyl-2beta,5beta,8beta-trimethylperhydro-8balpha,9-epoxy-5,8-ethanocyclopenta(1,2-b)indenyl) pyrrole-2-carboxylate
• Ryanodol, 3-(1H-pyrrole-2-carboxylate)
• Ryania speciosa, powdered stems of
• 1H-Pyrrole-2-carboxylic acid, dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester, [3S-(3α,4β,4aS*,6α,6aα,7α,8β,8aα,8bβ,9β,9aα)]-
• 6-(1α,5aβ,8aβ,9-Pentahydroxy-7β-isopropyl-2β,5β,8β-trimethylperhydro-8bα,9-epoxy-5,8-ethanocyclopenta[1,2-b]indenyl)pyrrol-2-carboxylat
• Pirrol-2-Carboxilato De 6-(1Α-5Aβ,8Aβ,9-Pentahidroxi-7Β-Isopropil-2Β,5Β,8Β-Trimetilperhidro-8Bα-9-Epoxi-5,8-Etanociclopenta[1,2-B]Indenilo
• Pyrrole-2-Carboxylate De 6-(1Α,5Aβ,8Aβ,9-Pentahydroxy-7Β-Isopropyl-2Β,5Β,8Β-Trimethylperhydro-8Bα,9-Epoxy-5,8-Ethanocyclopenta[1,2-B]Indenyle
• Ryanex
• Ryania (pesticide)
• Ryanodin

1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,6aS,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester

CAS: 15662-33-6

• Formula: C₂₅H₃₅NO₉
• Purity: ≥98%
• Color and Shape: Solid
• Molecular weight: 493.5467

Ryanodine

CAS: 15662-33-6

Ryanodine: a diterpenoid modulating Ca2+ release via ryanodine receptors; concentration-dependent effects; found in Ryania speciosa; …

• Formula: C₂₅H₃₅NO₉
• Purity: 98%
• Color and Shape: White Solid
• Molecular weight: 493.553

Ryanodine

CAS: 15662-33-6

Ryanodine receptor effector

• Formula: C₂₅H₃₅NO₉
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 493.55 g/mol