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CAS 15663-27-1

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Cisplatin

Description:
Cisplatin, with the CAS number 15663-27-1, is a platinum-based chemotherapy drug widely used in the treatment of various cancers, including testicular, ovarian, bladder, and lung cancers. Its chemical formula is cis-[Pt(NH3)2Cl2], indicating that it consists of a platinum atom coordinated to two ammonia molecules and two chloride ions. The compound is characterized by its square planar geometry, which is crucial for its biological activity. Cisplatin functions primarily by forming DNA cross-links, thereby inhibiting DNA replication and transcription, leading to apoptosis in rapidly dividing cancer cells. It is typically administered intravenously and can have side effects such as nephrotoxicity, nausea, and myelosuppression. The drug's effectiveness can be influenced by factors such as the presence of specific cellular proteins and the tumor microenvironment. Due to its mechanism of action, cisplatin is often used in combination with other chemotherapeutic agents to enhance therapeutic efficacy and overcome resistance.
Formula:Cl2H6N2Pt
InChI:InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
InChI key:InChIKey=LXZZYRPGZAFOLE-UHFFFAOYSA-L
SMILES:[Pt+2]([Cl-])([Cl-])([NH3])[NH3]
Synonyms:
  • (SP-4-2)-Diamminedichloroplatinum
  • Abiplatin
  • Biocisplatinum
  • Briplatin
  • CP Ethypharm
  • Cacp
  • Cddp
  • Cis-Platinum(Ii)Diammine Dichloride
  • Cismaplat
  • Cisplatin
  • See more synonyms
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