CAS 156722-18-8

Rostafuroxin

Description:

Rostafuroxin, identified by the CAS number 156722-18-8, is a chemical compound that functions primarily as a selective antagonist of the mineralocorticoid receptor. It is notable for its potential therapeutic applications, particularly in the treatment of conditions related to hypertension and heart failure. Rostafuroxin exhibits a unique mechanism of action, which involves modulating the effects of aldosterone, a hormone that plays a crucial role in regulating blood pressure and fluid balance. The compound is characterized by its specific binding affinity to the mineralocorticoid receptor, which distinguishes it from other similar agents. Additionally, Rostafuroxin has been studied for its effects on renal function and electrolyte balance, making it a subject of interest in cardiovascular pharmacology. Its chemical structure and properties contribute to its efficacy and safety profile, although detailed pharmacokinetic and pharmacodynamic data are essential for understanding its full therapeutic potential. As with any pharmaceutical agent, ongoing research continues to elucidate its mechanisms and optimize its clinical applications.

Formula: C₂₃H₃₄O₄

InChI: InChI=1S/C23H34O4/c1-20-8-5-17(24)13-15(20)3-4-19-18(20)6-9-21(2)22(25,10-11-23(19,21)26)16-7-12-27-14-16/h7,12,14-15,17-19,24-26H,3-6,8-11,13H2,1-2H3/t15-,17+,18+,19-,20+,21-,22+,23+/m1/s1

InChI key: InChIKey=AEAPORIZZWBIEX-DTBDINHYSA-N

SMILES: O[C@@]12[C@@](C)([C@](O)(CC1)C=3C=COC3)CC[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O)C5)[H])[H])[H]

Synonyms:

• (3Beta,5Beta,14Beta,17Alpha)-17-(Furan-3-Yl)Androstane-3,14,17-Triol
• (3β,5β,14β)-21,23-Epoxy-24-norchola-20,22-diene-3,14,17-triol
• 17-(3-Furyl)-5beta-androstane-3,14,17-triol
• 21,23-Epoxy-24-nor-14beta,5beta-chola-20,21-diene-3beta,14,17alpha-triol
• 24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3beta,5beta,14beta)-
• 24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-
• Pst 2238
• Rostafuroxin
• Rostafuroxin [INN]
• Unii-P848Lcx62B

24-​Norchola-​20,​22-​diene-​3,​14,​17-​triol, 21,​23-​epoxy-​, (3β,​5β,​14β)​-

CAS: 156722-18-8

Formula: C₂₃H₃₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 374.5137

Ref: IN-DA001OX3

Rostafuroxin

CAS: 156722-18-8

Rostafuroxin

Purity: ≥98%

Molecular weight: 374.51g/mol

Ref: 54-BUP05646

Rostafuroxin

CAS: 156722-18-8

Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.

Formula: C₂₃H₃₄O₄

Purity: 99.08% - >99.99%

Color and Shape: Solid

Molecular weight: 374.51

Ref: TM-T2621

(3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol

Controlled Product

CAS: 156722-18-8

Applications (3β,5β,14β)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol is used as a receptor blocker in the treatment of hypertension.
References Ferrandi, M. et al.: Sci. Trans. Med., 2, 59 (2010); Ferrandi, M. et al.: Cell. Mol. Biol., 52, 15 (2006);

Formula: C₂₃H₃₄O₄

Color and Shape: Neat

Molecular weight: 374.514

Ref: TR-R700585

(3²,5²,14²)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol

CAS: 156722-18-8

(3²,5²,14²)-21,23-Epoxy-24-Norchola-20,22-diene-3,14,17-triol is a biological sample that has antihypertensive activity and inhibitory properties. It has been shown to decrease the production of angiotensin II and epidermal growth factor (EGF) in vitro. It also has a binding affinity for cardiac DNA as well as inhibiting erythrocyte aggregation. The molecule also binds to α subunit of the GTPase protein family and inhibits tubule cell growth. This molecule may be useful in treating congestive heart failure or skin disorders such as psoriasis.

Formula: C₂₃H₃₄O₄

Purity: Min. 95%

Molecular weight: 374.51 g/mol

Ref: 3D-GGA72218