CAS 15686-51-8

Clemastine

Description:

Clemastine, with the CAS number 15686-51-8, is an antihistamine primarily used to alleviate allergy symptoms such as sneezing, runny nose, and itching. It belongs to the first generation of antihistamines, which means it can cross the blood-brain barrier, often resulting in sedative effects. Chemically, clemastine is classified as a diphenylmethanol derivative and features a complex structure that includes a piperidine ring. Its mechanism of action involves antagonism of the H1 histamine receptor, thereby inhibiting the effects of histamine, a key mediator in allergic responses. In addition to its antihistaminic properties, clemastine may also exhibit anticholinergic effects, which can contribute to its sedative properties. The substance is typically administered orally and is available in various formulations, including tablets and syrups. Due to its sedative effects, caution is advised when operating machinery or driving after taking clemastine. As with any medication, potential side effects may include drowsiness, dry mouth, and dizziness.

Formula: C₂₅H₃₀ClNO₅

InChI: InChI=1/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1

InChI key: InChIKey=YNNUSGIPVFPVBX-NHCUHLMSSA-N

SMILES: [C@@](OCC[C@@H]1N(C)CCC1)(C)(C2=CC=C(Cl)C=C2)C3=CC=CC=C3

Synonyms:

• Clemastine Hydrogen Fumarate
• (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine
• (2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine (2E)-but-2-enedioate
• Clemastine
• Clemastine Fumarate Salt
• Clemastinum
• (2R)-2-[2-[(1R)-1-(4-Chlorophenylethoxy)]Ethyl]-1-Methyl-2-Pyrrolidine Fumarate
• (+)-(2R)-2-[2-[[(R)-p-Chloro-alpha-methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine
• Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [R-(R*,R*)]-
• Pyrrolidine, 2-2-(1R)-1-(4-chlorophenyl)-1-phenylethoxyethyl-1-methyl-, (2R)-
• Pyrrolidine, 2-[2-[(p-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methyl-, (+)- (8CI)
• 2-{2-[1-(4-Chlorophenyl)-1-Phenylethoxy]Ethyl}-1-Methylpyrrolidine
• Meclastine
• Pyrrolidine, 2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, (2R)-
• Pyrrolidine, 2-[2-[(p-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methyl-, (+)-
• (2r)-2-[2-[(1r)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine but-2-enedioic acid
• [2R,(+)]-2-[2-[[(R)-1-(p-Chlorophenyl)-1-phenylethyl]oxy]ethyl]-1-methylpyrrolidine

Clemastine

CAS: 15686-51-8

Clemastine

Purity: ≥98%

Molecular weight: 343.89g/mol

Ref: 54-BUP13611

Clemastine fumarate

CAS: 15686-51-8

Formula: C₂₅H₃₀ClNO₅

Molecular weight: 459.96

Ref: 7W-GP3992

Clemastine

CAS: 15686-51-8

Formula: C₂₁H₂₆ClNO

Molecular weight: 343.9

Ref: ST-EA-CP-C169012

Clemastine

CAS: 15686-51-8

Clemastine (Meclastin) is an antagonist of the H1 receptor and exhibits anti-inflammatory effects.

Formula: C₂₁H₂₆ClNO

Purity: 99.21%

Color and Shape: Solid

Molecular weight: 343.89

Ref: TM-T19966