CAS 157-03-9: 6-Diazo-5-oxo-L-norleucine

Description: 6-Diazo-5-oxo-L-norleucine (CAS number 157-03-9) is a synthetic amino acid derivative known for its role as a potent inhibitor of the enzyme glutamine synthetase. This compound features a diazo group and a keto group, contributing to its reactivity and biological activity. It is characterized by its ability to mimic the structure of natural amino acids, which allows it to interact with various biological systems. The compound is typically used in biochemical research to study metabolic pathways and enzyme mechanisms, particularly in the context of amino acid metabolism. Its solubility in water and stability under physiological conditions make it suitable for laboratory applications. Additionally, 6-Diazo-5-oxo-L-norleucine has been investigated for its potential therapeutic applications, particularly in cancer research, due to its ability to disrupt metabolic processes in rapidly dividing cells. However, its use requires careful handling due to potential toxicity and the need for appropriate safety measures in laboratory settings.

Formula: C₆H₉N₃O₃

InChI: InChI=1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1

InChI key: InChIKey=YCWQAMGASJSUIP-YFKPBYRVSA-N

SMILES: [N-]=[N+]=CC(=O)CCC(N)C(=O)O

Synonyms:

• (1E,5S)-5-amino-5-carboxy-1-diazoniopent-1-en-2-olate
• (1Z,5S)-5-amino-5-carboxy-1-diazoniopent-1-en-2-olate
• (2S)-2-Amino-6-diazo-5-oxohexanoic acid
• 5-Amino-5-Carboxy-1-Diazoniopent-1-En-2-Olate
• 6-Diazen-1-Iumylidene-5-Oxonorleucine
• 6-Diazo-5-oxo-<span class="text-smallcaps">L</span>-norleucine
• <span class="text-smallcaps">L</span>-6-Diazo-5-oxonorleucine
• <span class="text-smallcaps">L</span>-DON
• <span class="text-smallcaps">L</span>-Norleucine, 6-diazo-5-oxo-
• DON (pharmaceutical)
• H-6-Diazo-5-oxo-Nle-OH
• NSC 7365
• Norleucine, 6-diazo-5-oxo-, <span class="text-smallcaps">L</span>-
• DON
• 6-Diazo-5-oxo-L-norleucine
• Norleucine, 6-diazo-5-oxo-, L-
• L-Norleucine, 6-diazo-5-oxo-

L-Norleucine, 6-diazo-5-oxo-

CAS: 157-03-9

• Formula: C₆H₉N₃O₃
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 171.154

6-Diazo-5-oxo-L-norleucine

CAS: 157-03-9

• Formula: C₆H₉N₃O₃
• Purity: ≥ 95.0%
• Color and Shape: Faint yellow to yellow or tan powder
• Molecular weight: 171.15

6-Diazo-5-oxo-L-nor-Leucine

CAS: 157-03-9

• Purity: 98.92%
• Molecular weight: 171.15g/mol

6-Diazo-5-oxo-L-nor-Leucine

CAS: 157-03-9

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).

• Formula: C₆H₉N₃O₃
• Purity: 98.04% - 98.93%
• Color and Shape: Solid
• Molecular weight: 171.15

6-Diazo-5-oxo-L-norleucine

CAS: 157-03-9

• Formula: C₆H₉N₃O₃
• Color and Shape: Light Yellow
• Molecular weight: 171.15

6-Diazo-5-oxo-L-norleucine

CAS: 157-03-9

Inhibitor of hexosamine biosynthetic pathway

• Formula: C₆H₉N₃O₃
• Purity: Min. 95%
• Color and Shape: Slightly Yellow Powder
• Molecular weight: 171.15 g/mol

H-6-Diazo-5-oxo-Nle-OH

CAS: 157-03-9

L-DON, which corresponds to Glu γ-diazomethyl ketone, inactivates rat renal phosphate-dependent glutaminase and is active …

• Formula: C₆H₉N₃O₃
• Purity: > 95%
• Color and Shape: Light Beige
• Molecular weight: 171.16

6-Diazo-5-oxo-L-norleucine

CAS: 157-03-9

• Molecular weight: 171.156005859375