CAS 157-03-9

6-Diazo-5-oxo-L-norleucine

Description:

6-Diazo-5-oxo-L-norleucine (CAS number 157-03-9) is a synthetic amino acid derivative known for its role as a potent inhibitor of the enzyme glutamine synthetase. This compound features a diazo group and a keto group, contributing to its reactivity and biological activity. It is characterized by its ability to mimic the structure of natural amino acids, which allows it to interact with various biological systems. The compound is typically used in biochemical research to study metabolic pathways and enzyme mechanisms, particularly in the context of amino acid metabolism. Its solubility in water and stability under physiological conditions make it suitable for laboratory applications. Additionally, 6-Diazo-5-oxo-L-norleucine has been investigated for its potential therapeutic applications, particularly in cancer research, due to its ability to disrupt metabolic processes in rapidly dividing cells. However, its use requires careful handling due to potential toxicity and the need for appropriate safety measures in laboratory settings.

Formula: C₆H₉N₃O₃

InChI: InChI=1/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H-,10,11,12)/b4-3+/t5-/m0/s1

InChI key: InChIKey=YCWQAMGASJSUIP-YFKPBYRVSA-N

SMILES: C(C[C@@H](C(O)=O)N)C(C=[N+]=[N-])=O

Synonyms:

• (1E,5S)-5-amino-5-carboxy-1-diazoniopent-1-en-2-olate
• (1Z,5S)-5-amino-5-carboxy-1-diazoniopent-1-en-2-olate
• (2S)-2-Amino-6-diazo-5-oxohexanoic acid
• 5-Amino-5-Carboxy-1-Diazoniopent-1-En-2-Olate
• 6-Diazen-1-Iumylidene-5-Oxonorleucine
• 6-Diazo-5-oxo-<span class="text-smallcaps">L</span>-norleucine
• <span class="text-smallcaps">L</span>-6-Diazo-5-oxonorleucine
• <span class="text-smallcaps">L</span>-DON
• <span class="text-smallcaps">L</span>-Norleucine, 6-diazo-5-oxo-
• DON (pharmaceutical)
• H-6-Diazo-5-oxo-Nle-OH
• NSC 7365
• Norleucine, 6-diazo-5-oxo-, <span class="text-smallcaps">L</span>-
• DON
• 6-Diazo-5-oxo-L-norleucine
• Norleucine, 6-diazo-5-oxo-, L-
• L-Norleucine, 6-diazo-5-oxo-
• (S)-2-aMino-6-diazo-5-oxohexanoic acid
• L-DON, 6-Diazo-5-oxo-L-2-aMinohexanoic acid, H-Glu(diazoMethylketone)-OH
• 6-DIAZO-5-OXO-NORLEUCINE
• H-6-DIAZO-5-OXO-L-NORLEUCINE
• 6-DIAZO-5-OXO-L-NORLEUCINE USP/EP/BP
• diazo-oxo-norleucine
• 6-diazo-5-oxo-l-norleucin
• (S)-2-Amino-6-diazo-5-oxocaproic acid, (S)-6-Diazo-5-oxo-L-norleucine
• 6-Diazo-5-oxo-L-norleucine≥ 99% (TBAH, Titration)
• H-NLE(6-DIAZO-5-OXO)-OH
• 5-Oxo-6-diazo-L-norleucine
• L-Nle(6-Diazo-5-oxo)-OH
• 6-diazo-5-oxo,l-norleucin
• (S)-2-Amino-6-diazo-5-oxocaproic acid, DON
• L-6-Diazo-5-oxonorleucine
• H-L-Don-OH
• 6-DIAZO-5-OXO-L-2-AMINOHEXANOIC ACID
• D2141
• L-DON
• (S)-2-AMINO-6-DIAZO-5-OXOCAPROIC ACID

L-Norleucine, 6-diazo-5-oxo-

CAS: 157-03-9

Formula: C₆H₉N₃O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 171.1540

Ref: IN-DA001P53

6-Diazo-5-oxo-L-nor-Leucine

CAS: 157-03-9

6-Diazo-5-oxo-L-nor-Leucine

Purity: ≥98%

Molecular weight: 171.15g/mol

Ref: 54-BUP12663

6-Diazo-5-oxo-L-norleucine

CAS: 157-03-9

Formula: C₆H₉N₃O₃

Purity: ≥ 95.0%

Color and Shape: Faint yellow to yellow or tan powder

Molecular weight: 171.15

Ref: 7W-GA1424

6-Diazo-5-oxo-L-nor-Leucine

CAS: 157-03-9

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).

Formula: C₆H₉N₃O₃

Purity: 98.04% - 98.93%

Color and Shape: Solid

Molecular weight: 171.15

Ref: TM-T8373

6-Diazo-5-oxo-L-norleucine

Controlled Product

CAS: 157-03-9

Formula: C₆H₉N₃O₃

Color and Shape: Light Yellow

Molecular weight: 171.15

Ref: TR-D679273

6-Diazo-5-oxo-L-norleucine

CAS: 157-03-9

Inhibitor of hexosamine biosynthetic pathway

Formula: C₆H₉N₃O₃

Purity: Min. 95%

Color and Shape: Slightly Yellow Powder

Molecular weight: 171.15 g/mol

Ref: 3D-FD49029