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CAS 157049-51-9

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31-homorifamycin W

Description:
31-Homorifamycin W is a chemical compound belonging to the rifamycin class of antibiotics, which are known for their efficacy against a variety of bacterial infections, particularly those caused by Mycobacterium species, including tuberculosis. This compound is characterized by its complex macrocyclic structure, which includes a naphthalenic core and various functional groups that contribute to its biological activity. The presence of specific substituents in its structure enhances its ability to inhibit bacterial RNA synthesis by binding to bacterial RNA polymerase. Additionally, 31-homorifamycin W exhibits a spectrum of antimicrobial activity, making it a subject of interest in medicinal chemistry and pharmaceutical research. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are critical for determining its therapeutic potential and safety profile. As with other rifamycins, resistance can develop, necessitating careful consideration in clinical applications. Overall, this compound represents a significant area of study in the development of new antibiotics to combat resistant bacterial strains.
Formula:C36H47NO11
InChI:InChI=1/C36H47NO11/c1-8-21-11-9-10-15(2)36(48)37-23-13-24(39)25-26(33(45)20(7)34(46)27(25)35(23)47)28(40)16(3)12-22(14-38)32(44)19(6)30(42)17(4)29(41)18(5)31(21)43/h9-13,17-19,21-22,29-32,38,41-46H,8,14H2,1-7H3,(H,37,48)/b11-9+,15-10-,16-12-
Synonyms:
  • 31-Homorifamycin W
  • (6Z,8E,19Z)-10-ethyl-11,13,15,17,22,24-hexahydroxy-18-(hydroxymethyl)-6,12,14,16,20,23-hexamethyl-11,12,13,14,15,16,17,18-octahydro-1H-3,25-methano-4-benzazacyclotricosine-1,5,21,26(4H,10H)-tetrone
  • Rifamycin W, 20-demethyl-20-ethyl- (9CI)
  • 31-homorifamycin W
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