CAS 157067-34-0

Docetaxel Metabolite M4

Description:

Docetaxel Metabolite M4, with the CAS number 157067-34-0, is a significant metabolite of the chemotherapeutic agent docetaxel, which is primarily used in the treatment of various cancers, including breast, lung, and prostate cancer. This metabolite is formed through the metabolic processes in the body, particularly involving cytochrome P450 enzymes. Characteristically, M4 retains some of the pharmacological properties of docetaxel, contributing to its therapeutic effects, although it may exhibit different potency and efficacy. The compound is typically characterized by its molecular structure, which includes a taxane core, and it may possess various functional groups that influence its solubility, stability, and interaction with biological targets. Understanding the characteristics of Docetaxel Metabolite M4 is crucial for evaluating its role in cancer treatment, potential side effects, and overall pharmacokinetics. Research into this metabolite can provide insights into the metabolism of docetaxel and its implications for personalized medicine in oncology.

Formula: C₄₃H₄₉NO₁₅

InChI: InChI=1/C43H49NO15/c1-21-25(56-36(51)31(48)29(23-14-10-8-11-15-23)44-37(52)40(5,6)59-38(44)53)19-43(54)34(57-35(50)24-16-12-9-13-17-24)32-41(7,33(49)30(47)28(21)39(43,3)4)26(46)18-27-42(32,20-55-27)58-22(2)45/h8-17,25-27,29-32,34,46-48,54H,18-20H2,1-7H3/t25-,26-,27+,29-,30+,31+,32?,34-,41+,42-,43+/m0/s1

Synonyms:

• Rpr 104943

Docetaxel Metabolite M4

CAS: 157067-34-0

Formula: C₄₃H₄₉NO₁₅

Color and Shape: White To Off-White Solid

Molecular weight: 819.86

Ref: 4Z-D-1916

Docetaxel Metabolite M4-d6

CAS: 157067-34-0

Formula: C₄₃H₄₃D₆NO₁₅

Color and Shape: White To Off-White Solid

Molecular weight: 825.89

Ref: 4Z-D-1918

Docetaxel Metabolite M4

Controlled Product

CAS: 157067-34-0

Applications The major human metabolite of Docetaxel (D494420), an antineoplastic.
References Van Asperen, J., et al.: J. Pharm. Sci., 86, 881 (1997), Bradshaw, D.M., et al.: J. Clin. Oncol., 16, 3674 (1998),

Formula: C₄₃H₄₉NO₁₅

Color and Shape: Neat

Molecular weight: 819.85

Ref: TR-D494410