CAS 15718-49-7

Guanosine, cyclic 2′,3′-(hydrogen phosphate), sodium salt (1:1)

Description:

Guanosine, cyclic 2′,3′-(hydrogen phosphate), sodium salt (1:1), commonly referred to as cyclic GMP (cGMP), is a nucleotide derivative that plays a crucial role in cellular signaling processes. It is characterized by a guanine base linked to a ribose sugar, which is further esterified with a phosphate group in a cyclic form. This cyclic structure is essential for its function as a second messenger in various biological pathways, particularly in the regulation of vascular smooth muscle relaxation and neurotransmission. The sodium salt form enhances its solubility in aqueous solutions, making it suitable for various biochemical applications. cGMP is involved in the activation of protein kinases and phosphodiesterases, influencing processes such as cell growth, differentiation, and apoptosis. Its stability and reactivity can be affected by environmental factors, including pH and temperature. Overall, cGMP is a vital molecule in the realm of biochemistry, with significant implications in pharmacology and therapeutic research.

Formula: C₁₀H₁₂N₅O₇P·Na

InChI: InChI=1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-6-5(3(1-16)20-9)21-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/t3-,5-,6-,9-;/m1./s1

InChI key: InChIKey=UNKYDTOROWVIHM-GWTDSMLYSA-N

SMILES: C(O)[C@H]1O[C@H]([C@]2([C@@]1(OP(=O)(O)O2)[H])[H])N3C4=C(N=C3)C(=O)N=C(N)N4.[Na]

Synonyms:

• 2-amino-9-[(3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]-3,9-dihydro-6H-purin-6-one
• Furo[3,4-d]-1,3,2-dioxaphosphole, uridine deriv.
• Guanosine 2′,3′-cyclic phosphate sodium salt
• Guanosine, cyclic 2',3'-(hydrogen phosphate), monosodium salt
• Guanosine, cyclic 2′,3′-(hydrogen phosphate), monosodium salt
• Guanosine, cyclic 2′,3′-(hydrogen phosphate), sodium salt (1:1)

Guanosine-2'',3''-cyclic monophosphate sodium salt

CAS: 15718-49-7

Formula: C₁₀H₁₁N₅O₇PNa

Molecular weight: 367.19

Ref: 7W-GE3176

Guanosine 2',3'-cyclic monophosphate sodium

CAS: 15718-49-7

Guanosine 2',3'-cyclic monophosphate sodium is a novel antiviral agent that has been shown to be effective against HIV, herpesviruses, and vaccinia virus. It is an activator of guanosine 3'-5' cyclic monophosphate (cGMP) and can be used as a substitute for the nucleoside guanosine 5'-triphosphate (GTP). Guanosine 2',3'-cyclic monophosphate sodium inhibits DNA synthesis by inhibiting the activity of ribonucleotide reductase and DNA polymerase. This drug also has anticancer properties, which may be due to its ability to inhibit the production of tumor necrosis factor-α (TNF-α) in mice with lung cancer.

Formula: C₁₀H₁₁N₅NaO₇P

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 367.19 g/mol

Ref: 3D-NG145480

Guanosine 2',3'-Cyclic Monophosphate Sodium Salt

Controlled Product

CAS: 15718-49-7

Formula: C₁₀H₁₁N₅O₇P·Na

Color and Shape: Neat

Molecular weight: 367.187

Ref: TR-G838713