CAS 157212-55-0: Bosentan monohydrate

Description: Bosentan monohydrate is a pharmaceutical compound primarily used in the treatment of pulmonary arterial hypertension (PAH). It is classified as an endothelin receptor antagonist, specifically targeting both endothelin-1 receptors (ETA and ETB), which play a significant role in vasoconstriction and vascular remodeling. The monohydrate form indicates that the compound contains one molecule of water per molecule of bosentan, which can influence its solubility and stability. Bosentan is typically presented as a white to off-white crystalline powder and is soluble in water and organic solvents. Its molecular formula reflects a complex structure that includes a sulfonamide group, contributing to its pharmacological activity. The compound is administered orally and is known to have a relatively long half-life, allowing for once or twice daily dosing. Common side effects may include liver enzyme elevations and potential interactions with other medications, necessitating regular monitoring of liver function in patients. Overall, bosentan monohydrate is an important therapeutic agent in managing PAH, improving exercise capacity and overall quality of life for affected individuals.

Formula: C₂₇H₃₁N₅O₇S

InChI: InChI=1S/C27H29N5O6S.H2O/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24;/h5-15,33H,16-17H2,1-4H3,(H,30,31,32);1H2

InChI key: InChIKey=SXTRWVVIEPWAKM-UHFFFAOYSA-N

SMILES: O=S(=O)(NC=1N=C(N=C(OCCO)C1OC=2C=CC=CC2OC)C3=NC=CC=N3)C4=CC=C(C=C4)C(C)(C)C.O

Synonyms:

• 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)(2,2'-bipyrimidin)-4-yl)benzenesulfonamide monohydrate
• 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide hydrate (1:1)
• Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]-, hydrate (1:1)
• Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]-, monohydrate
• Bosentan hydrate
• Stayveer

Bosentan

CAS: 157212-55-0

Sulfonamides used as drugs

• Formula: C₂₇H₂₉N₅O₆S·H₂₀
• Color and Shape: White Yellow Powder
• Molecular weight: 551.18385

Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-, hydrate (1:1)

CAS: 157212-55-0

• Formula: C₂₇H₃₁N₅O₇S
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 569.6293

Bosentan (hydrate)

CAS: 157212-55-0

• Purity: ≥98%
• Molecular weight: 569.63g/mol

Bosentan hydrate

CAS: 157212-55-0

• Formula: C₂₇H₂₉N₅O₆S·xH₂O
• Purity: ≥ 98.0% (dried basis)
• Color and Shape: White to off-white, light-yellow or faint beige powder
• Molecular weight: 569.63 (anhydrous)

Bosentan Hydrate

CAS: 157212-55-0

• Molecular weight: 569.63g/mol

Bosentan Monohydrate

CAS: 147536-97-8 157212-55-0

• Formula: C₂₇H₂₉N₅O₆S·H₂O
• Purity: >98.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 569.64

Bosentan Monohydrate

CAS: 157212-55-0

• Formula: C₂₇H₂₉N₅O₆S·H₂O
• Color and Shape: Neat
• Molecular weight: 569.63

Bosentan (hydrate)

CAS: 157212-55-0

Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A …

• Formula: C₂₇H₂₉N₅O₆S·H₂O
• Purity: 99.31% - 99.86%
• Color and Shape: White Powder
• Molecular weight: 569.63

Bosentan Hydrate

CAS: 157212-55-0

Applications Bosentan Hydrate, is an endothelin receptor antagonist, used as a vasodilator, and antihypertensive. References …

• Formula: C₂₇H₂₉N₅O₆S·H₂O
• Color and Shape: Neat
• Molecular weight: 569.63

Bosentan hydrate

CAS: 157212-55-0

Endothelin receptor antagonist; vasodilator

• Formula: C₂₇H₂₉N₅O₆S•H₂O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 569.63 g/mol