CAS 157212-55-0

Bosentan monohydrate

Description:

Bosentan monohydrate is a pharmaceutical compound primarily used in the treatment of pulmonary arterial hypertension (PAH). It is classified as an endothelin receptor antagonist, specifically targeting both endothelin-1 receptors (ETA and ETB), which play a significant role in vasoconstriction and vascular remodeling. The monohydrate form indicates that the compound contains one molecule of water per molecule of bosentan, which can influence its solubility and stability. Bosentan is typically presented as a white to off-white crystalline powder and is soluble in water and organic solvents. Its molecular formula reflects a complex structure that includes a sulfonamide group, contributing to its pharmacological activity. The compound is administered orally and is known to have a relatively long half-life, allowing for once or twice daily dosing. Common side effects may include liver enzyme elevations and potential interactions with other medications, necessitating regular monitoring of liver function in patients. Overall, bosentan monohydrate is an important therapeutic agent in managing PAH, improving exercise capacity and overall quality of life for affected individuals.

Formula: C₂₇H₃₁N₅O₇S

InChI: InChI=1/C27H29N5O6S.H2O/c1-27(2,3)18-10-12-19(13-11-18)39(34,35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-14-7-15-29-24;/h5-15,33H,16-17H2,1-4H3,(H,30,31,32);1H2

InChI key: InChIKey=SXTRWVVIEPWAKM-UHFFFAOYSA-N

SMILES: O(C=1C(NS(=O)(=O)C2=CC=C(C(C)(C)C)C=C2)=NC(=NC1OCCO)C=3N=CC=CN3)C4=C(OC)C=CC=C4.O

Synonyms:

• 4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)(2,2'-bipyrimidin)-4-yl)benzenesulfonamide monohydrate
• 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide hydrate (1:1)
• Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]-, hydrate (1:1)
• Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2′-bipyrimidin]-4-yl]-, monohydrate
• Bosentan hydrate
• Stayveer
• Bosentan monohydrate
• Bosetan
• Bosentan hydrate USP/EP/BP
• CS-170
• Bosentan
• Bosentan (200 mg)
• 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-Methoxyphenoxy)-2-(pyriMidin-2-yl)pyriMidin-4-yl]benzene-1-sulfonaMide
• 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide hydrate
• See B675900

Bosentan Monohydrate

CAS: 147536-97-8, 157212-55-0

Formula: C₂₇H₂₉N₅O₆S·H₂O

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 569.64

Ref: 3B-B5118

Bosentan

CAS: 157212-55-0

Sulfonamides used as drugs

Formula: C₂₇H₂₉N₅O₆S·H₂₀

Color and Shape: White Yellow Powder

Molecular weight: 551.18385

Ref: 45-1076115

4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide hydrate

CAS: 157212-55-0

Formula: C₂₇H₃₁N₅O₇S

Purity: 95%

Color and Shape: Solid

Molecular weight: 569.6293

Ref: IN-DA001PAX

Bosentan (hydrate)

CAS: 157212-55-0

Bosentan (hydrate)

Purity: ≥98%

Molecular weight: 569.63g/mol

Ref: 54-BUP11727

Bosentan Hydrate

CAS: 157212-55-0

Bosentan Hydrate

Purity: 99%

Molecular weight: 569.63g/mol

Ref: 54-OR1028270

Bosentan hydrate

CAS: 157212-55-0

Formula: C₂₇H₂₉N₅O₆S·xH₂O

Purity: ≥ 98.0% (dried basis)

Color and Shape: White to off-white, light-yellow or faint beige powder

Molecular weight: 569.63 (anhydrous)

Ref: 7W-GP5893

Bosentan Monohydrate

Controlled Product

CAS: 157212-55-0

Formula: C₂₇H₂₉N₅O₆S·H₂O

Color and Shape: Neat

Molecular weight: 569.63

Ref: 86-MM3369.00

Bosentan (hydrate)

CAS: 157212-55-0

Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.

Formula: C₂₇H₂₉N₅O₆S·H₂O

Purity: 99.31% - 99.86%

Color and Shape: White Powder

Molecular weight: 569.63

Ref: TM-T6265

Bosentan Hydrate

Controlled Product

CAS: 157212-55-0

Applications Bosentan Hydrate, is an endothelin receptor antagonist, used as a vasodilator, and antihypertensive.
References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)

Formula: C₂₇H₂₉N₅O₆S·H₂O

Color and Shape: Neat

Molecular weight: 569.63

Ref: TR-B675905

Bosentan hydrate

CAS: 157212-55-0

Endothelin receptor antagonist; vasodilator

Formula: C₂₇H₂₉N₅O₆S•H₂O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 569.63 g/mol

Ref: 3D-FB32083

Bosentan Monohydrate

CAS: 157212-55-0

Color and Shape: Neat

Ref: 61-FOR3369.00